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Published on: 2/10/2026

Is Dramamine Safe After 65? Side Effects & Risks for Seniors

Dramamine can be used after 65, but it is not risk-free; older adults are more prone to drowsiness, confusion, and falls, and it can worsen glaucoma or urinary retention and interact with sleep aids, pain medicines, and other drugs. There are several factors to consider, including your conditions, other medications, and safer non-drug options or the lowest short-term dose; see the complete guidance below to understand when it may be reasonable, when to avoid it, and when to speak with a clinician.

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Explanation

Is Dramamine Safe After 65? Side Effects & Risks for Seniors

Dramamine (dimenhydrinate) is a well-known over-the-counter medication used to prevent and treat motion sickness. Many older adults consider using it for travel-related nausea, dizziness, or vertigo. But once you're over 65, medications can affect the body differently. So, is Dramamine safe for seniors?

The short answer: Dramamine can be used after age 65, but it carries important risks that deserve careful consideration. Understanding how it works, its side effects, and safer alternatives can help you make a well-informed choice.


What Is Dramamine and How Does It Work?

Dramamine contains dimenhydrinate, an antihistamine with anticholinergic properties. It works by calming the inner ear and blocking certain signals in the brain that trigger nausea and vomiting.

It is commonly used for:

  • Motion sickness (car, boat, plane travel)
  • Dizziness or vertigo
  • Nausea related to movement

While effective, Dramamine also causes sedation and drying effects, which can be more pronounced in older adults.


Why Age Matters With Dramamine

As we age, the body processes medications more slowly. Changes in liver function, kidney function, and brain sensitivity mean that drugs like Dramamine can stay in the system longer and cause stronger effects.

Medical organizations that study medication safety in older adults, including geriatric and pharmacology experts, consistently note that first-generation antihistamines like Dramamine pose higher risks after age 65.

This doesn't mean Dramamine is automatically unsafe—but it does mean seniors should use it with extra caution.


Common Side Effects of Dramamine in Seniors

Some side effects of Dramamine are mild, while others can be more serious in older adults. Even at standard doses, seniors may experience stronger reactions.

Common Side Effects

  • Drowsiness or fatigue
  • Dry mouth, nose, or eyes
  • Blurred vision
  • Constipation
  • Mild dizziness

These effects may seem manageable, but they can interfere with daily activities, driving, or balance.

More Concerning Side Effects in Adults Over 65

  • Confusion or disorientation
  • Memory problems
  • Increased risk of falls
  • Difficulty urinating, especially in men with prostate enlargement
  • Worsening of glaucoma, particularly narrow-angle glaucoma
  • Low blood pressure when standing, leading to lightheadedness

Confusion and falls are especially important concerns, as they can lead to injuries or hospitalization.


Cognitive and Fall Risks: A Key Concern

One of the biggest reasons doctors urge caution with Dramamine in seniors is its anticholinergic effect. These drugs interfere with a brain chemical called acetylcholine, which is important for memory, alertness, and muscle control.

In older adults, anticholinergic medications have been associated with:

  • Short-term confusion or delirium
  • Slower reaction times
  • Increased fall risk
  • Worsening cognitive impairment in people with dementia

This does not mean Dramamine causes dementia, but it can temporarily worsen thinking and memory, especially in people already vulnerable.


Medical Conditions That Increase Risk

If you're over 65 and have any of the following conditions, Dramamine may not be the best choice unless a doctor specifically recommends it:

  • Glaucoma
  • Enlarged prostate or urinary retention
  • Asthma or chronic lung disease
  • Heart rhythm problems
  • Dementia or mild cognitive impairment
  • Parkinson's disease

Dramamine can also interact with other medications commonly used by seniors, including:

  • Sleep aids
  • Anxiety medications
  • Pain medications (especially opioids)
  • Muscle relaxants
  • Some antidepressants

Combining these can increase sedation and confusion.


Is There a "Safe" Dose of Dramamine for Seniors?

There is no special senior-specific dose listed on the label, but doctors often recommend:

  • Using the lowest effective dose
  • Taking it only when truly needed
  • Avoiding regular or long-term use

Many seniors find that even half a standard adult dose causes significant drowsiness. However, never split or adjust doses without checking the label or speaking to a healthcare professional.


Are There Safer Alternatives for Motion Sickness After 65?

Depending on the cause and severity of symptoms, some alternatives may carry fewer cognitive side effects.

Non-Medication Options

  • Sitting where motion is least noticeable (front seat of car, middle of boat)
  • Looking at the horizon
  • Fresh air and good ventilation
  • Avoiding heavy meals and alcohol before travel
  • Acupressure wrist bands

Other Medications

Some doctors may recommend different treatments depending on your health history. These may still have side effects, so medical guidance is essential.

Before deciding on any medication, you can use a free AI-powered symptom checker for Motion Sickness to help identify whether your symptoms match motion sickness or might be related to another condition that requires different treatment.


When Dramamine May Still Be Appropriate

Despite the risks, Dramamine may be reasonable for some seniors when:

  • Motion sickness is occasional and severe
  • Non-drug methods haven't worked
  • The person has no high-risk medical conditions
  • It's used short-term and at the lowest effective dose

In these cases, the benefits may outweigh the risks—but this decision should be individualized.


Warning Signs to Stop Dramamine and Get Help

Stop taking Dramamine and speak to a doctor right away if you or a loved one experiences:

  • New or worsening confusion
  • Severe dizziness or fainting
  • Trouble urinating
  • Rapid or irregular heartbeat
  • Hallucinations
  • Extreme sleepiness that interferes with daily function

Seek urgent medical care if symptoms feel severe, sudden, or life-threatening.


The Bottom Line: Is Dramamine Safe After 65?

Dramamine can be used after age 65, but it is not risk-free. Seniors are more sensitive to its side effects, especially confusion, drowsiness, and falls. Because of these risks, many healthcare professionals recommend using Dramamine only when necessary and exploring safer alternatives first.

If motion sickness is frequent, severe, or accompanied by other symptoms like ongoing dizziness, headaches, or balance problems, it's important to speak to a doctor. These symptoms can sometimes signal conditions that need medical evaluation rather than self-treatment.

Used thoughtfully and with guidance, Dramamine may still have a place—but informed decisions and medical advice are key to staying safe and well.

(References)

  • * Fick DM, Mion LC, Walls R, Roe C, Shubert TE, Cooper JW. Anticholinergic Drug Use and the Risk of Falls in Older Adults: A Systematic Review and Meta-analysis. J Am Geriatr Soc. 2017 Jun;65(6):1199-1207. doi: 10.1111/jgs.14815. Epub 2017 Apr 25. PMID: 28439871.

  • * Gomm W, von Holt K, Thomasius F, Heider D, Schiele J, König HH, Fritze F, Haenisch B, Kassner F, Riedel-Heller SG, Schröder J, Luck T, Röhr S. Anticholinergic drugs and risk of dementia: a systematic review and meta-analysis. Alzheimers Dement (Amst). 2016 Oct 25;2:e29-e38. doi: 10.1016/j.dadm.2016.09.001. PMID: 28066777; PMCID: PMC5194468.

  • * Veronese N, Demurtas J, Celotto S, Smith TO, Steves C, Soysal P, Pecorelli G, Ientile V, Baldereschi G, Tiveron F, Serrotti A, D'Ascoli G, Trevisan C. First-generation antihistamines and cognitive impairment in older adults: A systematic review. J Am Geriatr Soc. 2021 May;69(5):1377-1383. doi: 10.1111/jgs.17066. Epub 2021 Feb 17. PMID: 33595188.

  • * Villalba-Moreno ÁM, Pérez-Guerrero C, O'Shea E, Delgado-Silveira E, Salar-Ibáñez C, Montero-Errasquín V, Poveda-Andrés JL, Sanjurjo-Sáez M. The Anticholinergic Burden on Older Patients: A Systematic Review. J Clin Med. 2020 Jan 14;9(1):213. doi: 10.3390/jcm9010213. PMID: 31947849; PMCID: PMC7019623.

  • * Dauphinot V, Kera T, Geloen A, Forestier C, Kress C, Rouch I, Gabelle A, Fourrier-Réglat A, Berrut G, Béné J, Trivalle C, Voisin T, Maltête D, Robert P. Exposure to anticholinergic and sedative drugs and functional decline over 20 years in community-dwelling older adults: The PROOF cohort. J Am Geriatr Soc. 2023 Dec;71(12):3731-3742. doi: 10.1111/jgs.18567. Epub 2023 Sep 26. PMID: 37750800.

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