Dyshidrotic Eczema: Why Your Skin Is Blistering & Medical Next Steps

If you're noticing small, itchy blisters on your hands or feet, you may be dealing with dyshidrotic eczema. This skin condition can be uncomfortable and frustrating, especially when flare-ups seem to appear without warning.

The good news? Dyshidrotic eczema is treatable. With the right care plan and medical guidance, most people can control symptoms and reduce flare-ups.

Below, we'll explain what dyshidrotic eczema is, why your skin may be blistering, what causes it, and the medical next steps to take.

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What Is Dyshidrotic Eczema?

Dyshidrotic eczema (also called pompholyx) is a type of eczema that causes small, fluid-filled blisters. These blisters usually appear on:

• The sides of the fingers
• The palms of the hands
• The soles of the feet
• The edges of the toes

The blisters may be:

• Deep-seated and hard to pop
• Extremely itchy
• Painful or burning
• Filled with clear fluid

Flare-ups can last several weeks. After the blisters dry up, the skin may crack, peel, or feel tender.

This condition is not contagious.

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Why Is Your Skin Blistering?

The exact cause of dyshidrotic eczema isn't fully understood. However, research suggests it's related to immune system overactivity and skin barrier dysfunction.

Common triggers include:

1. Stress

Emotional stress is one of the most commonly reported triggers. Many people notice flare-ups during high-stress periods.

2. Allergies and Sensitivities

Exposure to certain substances can provoke a reaction, including:

• Nickel (found in jewelry, coins, and some foods)
• Cobalt
• Fragrances
• Harsh soaps or detergents
• Latex

3. Sweaty Hands and Feet

Excess moisture can worsen or trigger outbreaks.

4. Atopic Background

People with a history of:

• Atopic dermatitis
• Asthma
• Seasonal allergies

may be more prone to dyshidrotic eczema.

5. Fungal Infections

Sometimes a fungal infection (like athlete's foot) can trigger blistering on the hands, even if the infection is on the feet.

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What Dyshidrotic Eczema Looks and Feels Like

Symptoms often develop suddenly. You may notice:

• Small, tapioca-like blisters
• Intense itching before blisters appear
• Red, inflamed skin
• Cracking or scaling after blisters dry
• Thickened skin with repeated flare-ups

Blisters typically last 2–3 weeks. Scratching can make symptoms worse and increase the risk of infection.

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When Is It Something More Serious?

Most cases of dyshidrotic eczema are manageable. However, you should seek medical care if you notice:

• Severe swelling or pain
• Pus, crusting, or spreading redness
• Fever
• Blisters covering large areas
• Symptoms that don't improve with basic care

Infections can develop when the skin barrier is broken. These require prompt treatment.

If you're experiencing these symptoms and want to understand what might be causing them, try Ubie's free AI-powered Dyshidrotic Eczema symptom checker to get personalized insights in just a few minutes.

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How Is Dyshidrotic Eczema Diagnosed?

A doctor usually diagnoses dyshidrotic eczema through:

• A physical exam
• Medical history review
• Questions about allergies or stress

In some cases, your doctor may:

• Perform patch testing (to check for contact allergies)
• Do a skin scraping (to rule out fungal infection)
• Recommend blood tests if another condition is suspected

Getting an accurate diagnosis is important because other conditions—such as contact dermatitis, fungal infections, or autoimmune blistering diseases—can look similar.

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Medical Treatment Options

There is no permanent cure for dyshidrotic eczema, but treatment can control flare-ups and reduce symptoms.

1. Topical Corticosteroids

These prescription creams reduce inflammation and itching. They are often the first-line treatment.

2. Calcineurin Inhibitors

Non-steroid creams (like tacrolimus) may be used for sensitive areas or long-term management.

3. Oral Steroids

Short courses may be prescribed for severe outbreaks.

4. Phototherapy

Controlled ultraviolet (UV) light therapy may help chronic cases.

5. Treatment for Infections

If bacteria or fungus are present, antibiotics or antifungal medications may be necessary.

6. Advanced Therapies

In severe or chronic cases, dermatologists may recommend systemic medications that regulate the immune system.

Always follow your doctor's instructions when using prescription treatments. Overusing topical steroids can thin the skin.

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At-Home Care to Support Healing

Medical treatment works best when combined with consistent skin care.

Here's what helps:

Protect Your Skin

• Wear cotton gloves under rubber gloves when cleaning.
• Avoid prolonged water exposure.
• Use lukewarm—not hot—water.

Moisturize Frequently

Apply fragrance-free, thick creams or ointments several times a day, especially after washing hands.

Avoid Known Triggers

If nickel or certain products trigger flare-ups, limit exposure.

Manage Sweat

• Keep hands and feet dry.
• Change socks frequently.
• Use moisture-wicking fabrics.

Reduce Stress

Stress management techniques such as:

• Regular exercise
• Meditation
• Deep breathing
• Adequate sleep

can reduce flare frequency.

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Can Dyshidrotic Eczema Go Away?

For some people, dyshidrotic eczema occurs occasionally and improves over time. For others, it becomes a recurring condition.

Chronic cases may lead to:

• Thickened skin
• Persistent dryness
• Frequent relapses

While it may not disappear completely, proper treatment significantly improves quality of life.

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Preventing Future Flare-Ups

You may not be able to eliminate dyshidrotic eczema entirely, but you can reduce flare-ups by:

• Identifying and avoiding triggers
• Keeping skin well moisturized
• Treating fungal infections promptly
• Managing stress
• Wearing protective gloves during wet work

Keeping a symptom diary can help you notice patterns.

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When to Speak to a Doctor

You should speak to a doctor if:

• You are unsure whether it's dyshidrotic eczema
• Blisters are worsening or spreading
• You suspect infection
• Pain interferes with daily life
• Over-the-counter treatments aren't helping

While dyshidrotic eczema itself is usually not life-threatening, complications such as infection can become serious if untreated. Always seek urgent medical care if you experience high fever, severe swelling, or rapidly spreading redness.

A healthcare professional can confirm the diagnosis and create a safe, personalized treatment plan.

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The Bottom Line

Dyshidrotic eczema is a common form of eczema that causes itchy, fluid-filled blisters on the hands and feet. Though uncomfortable, it is manageable with proper treatment and trigger control.

Understanding why your skin is blistering is the first step. From there, medical evaluation, prescription treatments, and consistent skin care can significantly reduce symptoms and prevent complications.

If you're uncertain about your symptoms, consider starting with a free online symptom check for Dyshidrotic Eczema and then follow up with a qualified healthcare provider.

When in doubt, speak to a doctor—especially if symptoms are severe, painful, or show signs of infection. Early treatment leads to better outcomes and healthier skin.