Ehlers Danlos Syndrome: Symptoms in Women 30–45 & Next Steps

Ehlers danlos syndrome (EDS) is a group of inherited connective tissue disorders that affect how the body produces collagen. Collagen is a key protein that gives strength and structure to your skin, joints, blood vessels, and organs. When collagen doesn't work properly, tissues can become fragile, overly flexible, or prone to injury.

Many women between 30 and 45 years old begin to notice symptoms that interfere with daily life—especially if earlier signs were mild or overlooked. Hormonal shifts, pregnancy, injuries, or years of joint strain can make symptoms more noticeable during this stage of life.

This guide explains common symptoms, what to watch for, and practical next steps.

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What Is Ehlers Danlos Syndrome?

Ehlers danlos syndrome is not one single condition. There are 13 recognized subtypes, each with different features and levels of severity.

The most common type is hypermobile EDS (hEDS). Other types, such as classical EDS and vascular EDS, are less common but may carry more serious risks.

While EDS is genetic, some people are not diagnosed until adulthood—especially women, who may have been told they were simply "flexible" or "double-jointed" when younger.

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Why Symptoms May Worsen in Women 30–45

Women in this age group often experience:

• Hormonal changes (including perimenopause)
• Pregnancy and childbirth
• Increased physical demands from work or caregiving
• Accumulated joint wear and tear

Estrogen influences collagen strength. Changes in hormone levels may contribute to increased joint instability or pain during this phase of life.

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Common Symptoms of Ehlers Danlos Syndrome in Women 30–45

Symptoms vary by subtype, but the following are common in hypermobile and classical types:

1. Joint Hypermobility

• Joints that bend beyond the normal range
• Frequent sprains or strains
• Joint instability (shoulders, knees, hips, fingers)
• Recurrent dislocations or subluxations (partial dislocations)

Some women report that they were flexible as children but now experience chronic joint pain instead of flexibility being an advantage.

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2. Chronic Pain

Chronic pain is one of the most disruptive symptoms of ehlers danlos syndrome.

• Aching muscles and joints
• Widespread body pain
• Neck and back pain
• Headaches or migraines

Pain may worsen after physical activity or prolonged sitting/standing.

Because widespread chronic pain can also be a hallmark of Fibromyalgia, many women find it helpful to check their symptoms for this overlapping condition to better understand their full health picture.

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3. Fatigue

Persistent fatigue is common and can feel overwhelming.

• Feeling drained even after sleep
• Difficulty maintaining energy throughout the day
• Brain fog or trouble concentrating

Fatigue may be linked to chronic pain, poor sleep, autonomic dysfunction, or associated conditions.

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4. Skin Changes

Depending on the type of ehlers danlos syndrome, skin may be:

• Soft or velvety
• Stretchy
• Fragile or prone to bruising
• Slow to heal
• Prone to widened scars

In classical EDS, abnormal scarring is more noticeable.

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5. Pelvic and Gynecologic Issues

Women 30–45 may notice:

• Pelvic organ prolapse
• Urinary incontinence
• Pain during intercourse
• Heavy or painful periods

Pregnancy can increase strain on already weakened connective tissues.

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6. Digestive Problems

Connective tissue is also present in the digestive tract. Some women experience:

• Bloating
• Constipation
• Acid reflux
• Irritable bowel–like symptoms

These issues can significantly affect quality of life.

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7. Cardiovascular Concerns (Subtype-Dependent)

Most people with hypermobile EDS do not have life-threatening vascular issues. However, certain subtypes—especially vascular ehlers danlos syndrome (vEDS)—can affect blood vessels and organs.

Possible warning signs include:

• Easy or unexplained bruising
• Thin, translucent skin
• Family history of arterial rupture
• Sudden severe chest or abdominal pain

If you experience sudden, severe pain in the chest, abdomen, or head, seek immediate medical care. These symptoms can be life-threatening and require urgent evaluation.

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How Ehlers Danlos Syndrome Is Diagnosed

Diagnosis usually involves:

• Detailed medical history
• Family history
• Physical exam (including Beighton score for joint hypermobility)
• Genetic testing (for certain subtypes)

Currently, hypermobile EDS does not have a confirmed genetic test, so diagnosis is based on clinical criteria.

Because symptoms overlap with other conditions—such as fibromyalgia, autoimmune disorders, or thyroid disease—your doctor may run additional tests to rule out other causes.

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When to Speak to a Doctor

You should speak to a doctor if you experience:

• Frequent joint dislocations
• Chronic unexplained pain
• Severe fatigue affecting daily life
• Recurrent sprains with minimal injury
• Pelvic organ prolapse at a young age
• Family history of vascular complications
• Sudden severe chest, abdominal, or head pain

Some forms of ehlers danlos syndrome can carry serious risks. Prompt medical evaluation is important, especially if symptoms are worsening or severe.

If something feels "not right," trust that instinct and seek medical advice.

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Next Steps If You Suspect Ehlers Danlos Syndrome

If you think you may have ehlers danlos syndrome, consider the following:

1. Track Your Symptoms

Write down:

• When pain started
• Frequency of dislocations
• Fatigue patterns
• Skin concerns
• Family history

This helps your doctor see patterns.

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2. Request a Referral

You may need to see:

• A rheumatologist
• A geneticist
• A cardiologist (if vascular concerns)
• A pelvic floor specialist
• A pain management specialist

Not all doctors are familiar with EDS, so a specialist referral can be helpful.

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3. Physical Therapy

Targeted physical therapy is one of the most effective treatments for hypermobile ehlers danlos syndrome.

Focus areas include:

• Joint stabilization
• Muscle strengthening
• Core stability
• Proprioception training (joint awareness)

Avoid overly aggressive stretching, which may worsen instability.

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4. Pain Management Strategies

Pain management may include:

• Low-impact exercise (swimming, Pilates, walking)
• Heat or cold therapy
• Support braces (short-term use)
• Medication if prescribed
• Cognitive behavioral therapy for chronic pain coping

A multi-disciplinary approach often works best.

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5. Lifestyle Adjustments

Small changes can make a big difference:

• Pacing activities to prevent flare-ups
• Ergonomic work setups
• Supportive footwear
• Adequate hydration
• Sleep hygiene

These strategies reduce strain on connective tissue.

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Mental and Emotional Impact

Living with ehlers danlos syndrome can be frustrating—especially if diagnosis took years. Many women report feeling dismissed before receiving answers.

Chronic pain and fatigue can affect:

• Mood
• Relationships
• Career
• Self-confidence

Seeking mental health support is not a sign of weakness. It is part of comprehensive care.

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Is Ehlers Danlos Syndrome Life-Threatening?

Most people with hypermobile ehlers danlos syndrome have a normal life expectancy. However:

• Certain subtypes (like vascular EDS) can carry serious risks.
• Early diagnosis helps reduce complications.
• Monitoring and appropriate care improve long-term outcomes.

Do not ignore severe or sudden symptoms. Some complications require urgent care.

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Key Takeaways

• Ehlers danlos syndrome is a connective tissue disorder affecting joints, skin, and sometimes organs.
• Women 30–45 may notice worsening symptoms due to hormonal and life-stage changes.
• Common symptoms include joint instability, chronic pain, fatigue, and pelvic issues.
• Diagnosis may require specialist evaluation.
• Physical therapy and lifestyle strategies can significantly improve quality of life.
• Serious or sudden symptoms require immediate medical attention.

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Final Word

If you recognize yourself in these symptoms, you are not imagining them—and you are not alone. Ehlers danlos syndrome can be complex, but it is manageable with the right support.

Start by documenting your symptoms and scheduling a conversation with a qualified healthcare professional. Speak to a doctor promptly about anything severe, sudden, or potentially life-threatening.

Taking action early can protect your health, reduce complications, and help you regain control over your daily life.