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Published on: 5/6/2025

Can Fatigue Mimic the Symptoms of Depression, and How Might Low Testosterone Contribute to This?

Yes, fatigue can look like depression, and low testosterone may make this worse by affecting energy and mood.

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Explanation

Fatigue means feeling very tired and low on energy. People with fatigue might seem sad or uninterested, much like those with depression. This overlap can make it tricky to tell the two apart because both share signs such as low energy, difficulty concentrating, and a loss of interest in daily activities. Low testosterone, a hormone found in both men and women, can lower energy levels and contribute to feelings of sadness or depression. Some studies have found that men with low testosterone are more likely to experience these low energy and mood symptoms. When testosterone levels are too low, it may affect the brain and body in ways that mimic depression, making people feel even more tired and less motivated. In some cases, treating low testosterone can help ease these symptoms, but it is important to work with a healthcare provider for proper testing and treatment decisions. This explanation helps us understand that while fatigue and depression share features, factors like low testosterone can play a key role in how these symptoms show up and overlap.

(References)

  • Indirli R, Lanzi V, Arosio M, Mantovani G, Ferrante E. The association of hypogonadism with depression and its treatments. Front Endocrinol (Lausanne). 2023 Aug 10;14:1198437. doi: 10.3389/fendo.2023.1198437. PMID: 37635965; PMCID: PMC10449581.

  • Määttänen I, Gluschkoff K, Komulainen K, Airaksinen J, Savelieva K, García-Velázquez R, Jokela M. Testosterone and specific symptoms of depression: Evidence from NHANES 2011-2016. Compr Psychoneuroendocrinol. 2021 Mar 10;6:100044. doi: 10.1016/j.cpnec.2021.100044. PMID: 35757365; PMCID: PMC9216439.

  • Anderson DJ, Vazirnia P, Loehr C, Sternfels W, Hasoon J, Viswanath O, Kaye AD, Urits I. Testosterone Replacement Therapy in the Treatment of Depression. Health Psychol Res. 2022 Nov 26;10(4):38956. doi: 10.52965/001c.38956. PMID: 36452903; PMCID: PMC9704723.

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