Our Services
Medical Information
Helpful Resources
Published on: 2/24/2026
Fibromyalgia is a real, treatable nervous system pain-processing disorder where central sensitization makes nerves overly sensitive, with neurotransmitter imbalances and autonomic dysregulation driving widespread pain, fatigue, sleep issues, and fibro fog without causing tissue damage.
Next steps include seeing a doctor to confirm the pattern and rule out thyroid disease, autoimmune conditions, or vitamin deficiencies, then using a multi-layered plan with targeted medications, sleep optimization, gentle movement, stress reduction or CBT, and physical therapy while watching for urgent red flags like chest pain or new weakness. There are several factors to consider, and important details that could change your next steps are explained below.
Fibromyalgia is a chronic pain condition that affects how your brain and nerves process pain signals. If you've ever felt widespread aches, deep fatigue, or mental "fog" without a clear injury or inflammation to explain it, fibromyalgia may be part of the picture.
It is real. It is medical. And it is treatable.
Understanding why fibromyalgia happens — and what steps to take next — can help you regain control and improve your quality of life.
Fibromyalgia is a disorder of pain processing. Unlike arthritis or autoimmune diseases, it does not cause joint damage or visible inflammation. Instead, it changes how your nervous system interprets signals.
In simple terms:
Doctors often refer to this as central sensitization.
Fibromyalgia affects millions of people worldwide and is more common in women, though men and children can also develop it.
Researchers don't believe fibromyalgia is caused by a single problem. Instead, it appears to involve a combination of nervous system changes.
Here's what credible medical research shows:
Brain imaging studies show that people with fibromyalgia have:
Your brain essentially reacts more strongly to normal input.
Certain brain chemicals help regulate pain and mood. In fibromyalgia:
These chemical shifts help explain both chronic pain and mood symptoms.
The autonomic nervous system (which controls heart rate, digestion, and stress response) may become dysregulated. This can lead to:
This is why fibromyalgia affects more than just muscles.
Fibromyalgia often begins after:
Genetics may also play a role. If a close family member has fibromyalgia, your risk may be higher.
Fibromyalgia is defined by widespread pain lasting at least three months.
But pain is only part of the story.
Symptoms often fluctuate. You may have good days and flare-ups.
There is no single blood test or scan that confirms fibromyalgia. Diagnosis is based on:
Your doctor may order tests to exclude:
If you're experiencing widespread pain, fatigue, or other symptoms described above, Ubie's free AI-powered Fibromyalgia symptom checker can help you understand whether your experience aligns with typical patterns and prepare for a more informed conversation with your doctor.
Fibromyalgia is not life-threatening. It does not damage joints, muscles, or organs.
However, it can significantly affect:
Because chronic pain is exhausting — physically and mentally.
It's important not to dismiss symptoms as "just stress" or "all in your head." Fibromyalgia is a recognized medical condition supported by decades of research.
If fibromyalgia may be affecting you, here's a practical roadmap.
Start with your primary care physician. In some cases, you may be referred to:
Be prepared to describe:
If you experience chest pain, sudden weakness, high fever, unexplained weight loss, or neurological symptoms, seek urgent medical care. Always speak to a doctor about anything that could be serious or life threatening.
There is no single cure for fibromyalgia. Treatment works best when it combines several approaches.
These are prescribed not because fibromyalgia is "psychological," but because they adjust pain processing systems.
Poor sleep worsens fibromyalgia symptoms. Improving sleep quality is often a turning point.
Helpful strategies include:
Deep sleep helps reset pain pathways.
Exercise can sound impossible when you're in pain. But research consistently shows that low-impact movement improves fibromyalgia symptoms over time.
Start small:
Consistency matters more than intensity.
Stress worsens nervous system sensitization.
Cognitive behavioral therapy (CBT), mindfulness practices, and stress-reduction techniques can:
This is about calming the nervous system — not dismissing pain.
A physical therapist familiar with fibromyalgia can help:
It's important to clarify what fibromyalgia is not:
Understanding this helps reduce fear. Pain does not equal structural damage in fibromyalgia.
Many people with fibromyalgia live full, productive lives. The key is learning how your body responds and managing energy wisely.
Helpful principles include:
Improvement is often gradual — not overnight.
While fibromyalgia itself is not dangerous, some symptoms should never be ignored.
Seek urgent care if you experience:
Always speak to a doctor about any symptom that feels severe, unusual, or rapidly worsening.
Fibromyalgia is a condition where the nervous system becomes overly sensitive, causing widespread pain, fatigue, and cognitive challenges. It does not mean your body is damaged — but it does mean your pain processing system needs support.
If your symptoms match what you've read, taking Ubie's free Fibromyalgia symptom checker can help you organize your symptoms and guide a more productive conversation with your healthcare provider.
Most importantly:
Speak to a doctor about your symptoms — especially if anything could be serious or life threatening. With the right combination of medical care, lifestyle adjustments, and support, many people with fibromyalgia see meaningful improvement over time.
(References)
* Staud R. Central sensitization in fibromyalgia: a systematic review. Int J Clin Pract. 2018 Sep;72(9):e13222. doi: 10.1111/ijcp.13222. Epub 2018 Jul 13. PMID: 30006935; PMCID: PMC6376829.
* Macfarlane GJ, Kronisch C, Dean LE, et al. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. 2017 Feb;76(2):318-328. doi: 10.1136/annrheumdis-2016-210165. Epub 2016 Sep 27. PMID: 27680733.
* Sluka KA, Clauw DJ. Neurobiology of fibromyalgia. J Pain. 2016 Mar;17(3 Suppl):S11-S21. doi: 10.1016/j.jpain.2016.01.006. PMID: 26993188; PMCID: PMC4780516.
* Häuser W, Fitzcharles MA. Fibromyalgia: diagnosis and management. Handb Clin Neurol. 2020;175:317-326. doi: 10.1016/B978-0-444-64123-6.00021-3. PMID: 33070908.
* Uçeyler N, Kleggetveit IP, Fasolino V, et al. Small fiber neuropathy in fibromyalgia and its clinical implications. Pain Rep. 2021 Jun 28;6(3):e883. doi: 10.1097/PR9.0000000000000883. PMID: 34180173; PMCID: PMC8245136.
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.