Is there a genetic component to restless leg syndrome?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Restless leg syndrome (RLS) often has a genetic component and can run in families. Studies show that up to 60% of people with RLS have a family history of the condition, and researchers have identified several gene variants linked to a higher risk of developing it. When RLS is inherited, symptoms typically appear before age 40.

If you're experiencing uncomfortable leg sensations, an urge to move your legs, or sleep disruption, don't guess at the cause. A free, instant, online symptom check can help you understand what may be behind your symptoms and guide your next steps—whether that's lifestyle changes, seeing a doctor, or exploring treatment options.

Reviewed for medical accuracy: 07/14/2026

Important Next Steps

Learn if restless legs need care today Discover likely causes of restless leg syndrome See whether symptoms suggest restless leg syndrome Find OTC options for restless leg relief Find a doctor for restless leg syndrome Discover home remedies for restless leg syndrome Understand if symptoms could be restless leg syndrome

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Explanation

Restless leg syndrome (RLS) is a condition where people feel an uncontrollable urge to move their legs, often causing discomfort. Research shows that genetics play a role in RLS, meaning it can be passed down from parents to children.

Genetic Factors

Family History: Many people with RLS have family members who also have it. This suggests that genes are involved.
Specific Genes: Scientists have found certain genes that are linked to RLS. These genes can affect how the brain processes signals, leading to the symptoms of RLS.

Conclusion

Understanding the genetic link can help in diagnosing RLS and finding better treatments in the future. If you're experiencing symptoms like an uncontrollable urge to move your legs or discomfort, take Ubie's free AI-powered symptom checker to help identify what might be causing your symptoms and get personalized guidance on next steps.

(References)

Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, & Agúndez JAG. (2018). Genetics of restless legs syndrome: An update. Sleep medicine reviews, 29033051.
Winkelmann J, Schormair B, Xiong L, Dion PA, Rye DB, & Rouleau GA. (2017). Genetics of restless legs syndrome. Sleep medicine, 28065402.
Rye DB. (2015). The Molecular Genetics of Restless Legs Syndrome. Sleep medicine clinics, 26329432.

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