When is surgery needed for Glaucoma instead of eye drops?

When you're diagnosed with glaucoma, lowering your eye pressure early is key to preventing vision loss. Most people start with eye drops, but surgery becomes necessary when medications aren't enough or aren't well tolerated. Below is a clear guide to help you understand when glaucoma surgery is recommended instead of—or in addition to—eye drops.

Why eye drops are first-line therapy

Eye drops are typically the first treatment because they:

• Reduce the pressure inside your eye (intraocular pressure, or IOP) by either decreasing fluid production or improving fluid drainage
• Are non-invasive
• Can be adjusted or combined if one medication isn't enough
• Tend to have fewer serious risks than surgery

The landmark Five-Year Glaucoma Treatment Study (Gordon MO et al., 2005) showed that, over five years, medical therapy controlled pressure in many patients with early glaucoma as well as initial surgery did. However, some people still experienced progression or couldn't tolerate the drops.

When eye drops aren't enough

Your doctor will monitor your eye pressure, visual field tests and the appearance of your optic nerve. Surgery is generally considered when one or more of these occur:

1. Uncontrolled IOP despite maximum medical therapy

   • You're using multiple eye drops at the highest safe doses and your pressure remains above your target.
   • Trials like the one by Gordon MO et al. found that some patients on three or more drugs still needed surgery to hit their goal pressure.

2. Progressive vision loss or optic nerve damage

   • Your visual fields worsen on testing, even though you're compliant with drops.
   • The European Glaucoma Society (2014) guidelines recommend surgery if damage continues despite adequate medical treatment.

3. Poor tolerance or side effects

   • Eye drops can cause redness, burning, dry eyes or systemic effects (e.g., fatigue, low heart rate).
   • If side effects make you skip doses—or you have sensitivities to preservatives—surgery may be a better long-term solution.

4. Non-compliance or difficulty with administration

   • Some people struggle with dexterity (arthritis, tremor) or cognition and miss doses.
   • Surgery reduces dependence on daily eye drops.

5. Advanced or high-risk glaucoma

   • Very high IOP at diagnosis (e.g., angle-closure crisis), or rapid progression, may call for early surgical intervention.
   • In certain populations, early trabeculectomy can be safer for preserving vision.

6. Secondary glaucomas

   • Inflammatory, uveitic or neovascular glaucoma often respond poorly to medications alone.
   • Surgery (or laser) is frequently needed sooner.

Types of glaucoma surgery

Once surgery is indicated, options include:

• Laser procedures

  • Selective laser trabeculoplasty (SLT): Targets drainage tissue to improve outflow. Can be done in the office, with minimal discomfort. Often used before or instead of adding another drop.
  • Argon laser trabeculoplasty (ALT): Similar to SLT but uses a different laser.

• Filtering surgeries

  • Trabeculectomy: Creates a new drainage channel under the conjunctiva. Effective at lowering IOP but carries risks of infection, scarring and low pressure.
  • Tube shunts (glaucoma drainage devices): Implants that divert fluid to an external reservoir. Useful in eyes with scarring or prior failed surgery.

• Minimally invasive glaucoma surgery (MIGS)

  • Newer, less invasive procedures (e.g., iStent, Hydrus stent, Kahook Dual Blade).
  • Safer and faster recovery, but often less effective for very high pressures. Best for mild-to-moderate glaucoma, usually combined with cataract surgery.

Your doctor will recommend the procedure that best balances risk, expected pressure reduction and your overall eye health.

Balancing benefits and risks

No surgery is risk-free. Common considerations include:

• Success rate: Trabeculectomy lowers pressure most dramatically (often to mid-teens mmHg), but MIGS may only reduce IOP modestly.
• Complications: Early filtering surgery can cause low pressure (hypotony), infection (endophthalmitis) or scarring requiring needling.
• Recovery: Laser and MIGS typically have quicker visual recovery than trabeculectomy or tube shunts.
• Long-term care: You may still need eye drops after surgery, though often at lower doses or fewer medications.

When to talk about surgery

Discuss these questions with your ophthalmologist:

• Am I meeting my target IOP on drops alone?
• Do I have any side effects or trouble using my medications?
• Is my glaucoma stable or progressing on current therapy?
• Which surgical option fits my stage of disease and lifestyle?

Early versus delayed surgery

The European Glaucoma Society guidelines highlight that waiting too long can risk irreversible vision loss. On the other hand, premature surgery may expose you to avoidable risks. Together, you and your doctor will weigh:

• Severity of disease
• Rate of progression
• Quality of life on drops
• Your comfort accepting surgical risks

Tracking symptoms at home

If you notice new symptoms—sudden eye pain, blurred vision, halos around lights, headache—don't wait. These could signal an acute glaucoma attack, which requires immediate medical attention. You can check your symptoms with Ubie's free AI tool for acute glaucoma attack to help determine if you need to seek emergency care right away.

Key takeaways

• Eye drops are the usual first step in glaucoma treatment.
• Surgery is indicated when drops can't reach your target pressure, cause side effects, or when glaucoma progresses despite good compliance.
• Options range from office-based laser treatments to more invasive filtering surgeries and shunt implants.
• Minimally invasive procedures offer faster recovery but may not achieve very low pressures.
• Your individual risk factors and disease stage guide the timing and type of surgery.

Always keep an open dialogue with your ophthalmologist. Together, you'll choose the safest, most effective approach to protect your vision.

Speak to a doctor about anything that could be life threatening or serious.