Published on: 7/24/2025
What percentage of GLP-1 users experience muscle loss?
Some people using GLP-1 medications may experience muscle loss, but the exact percentage is not clear.
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Explanation
Glucagon-like peptide-1 (GLP-1) medications are used to help with weight loss and managing blood sugar. Some studies suggest that these medications might cause a decrease in muscle mass, also known as lean body mass.
Research discusses changes in lean body mass with GLP-1 use, but often does not provide specific percentages of users experiencing muscle loss. Studies examining the effects of GLP-1 receptor agonists also do not always specify how many people lose muscle. Reviews of the impact of specific GLP-1 medications, like semaglutide, on lean mass typically do not give a precise percentage of muscle loss.
While these references discuss the potential for muscle loss with GLP-1 medications, they do not specify how many people are affected. If you are using these medications and have concerns about muscle loss, it might be helpful to discuss this with your healthcare provider.
(References)
- Neeland IJ, Linge J, & Birkenfeld AL. (2024). Changes in lean body mass with glucagon-like peptide-1- .... Diabetes, obesity & metabolism, 38937282.
- Dubin RL, Heymsfield SB, Ravussin E, & Greenway FL. (2024). Glucagon-like peptide-1 receptor agonist-based agents .... Diabetes, obesity & metabolism, 39344838.
- Bikou A, Dermiki-Gkana F, Penteris M, Constantinides TK, & Kontogiorgis C. (2024). A systematic review of the effect of semaglutide on lean mass. Expert opinion on pharmacotherapy, 38629387.
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