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Published on: 3/5/2025

Is Low Testosterone Genetic?

Yes, genetics can play a role in low testosterone. Some men inherit genes or genetic conditions, like Klinefelter syndrome, that make them more likely to have low testosterone levels.

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Explanation

Low testosterone means a man does not have enough of the hormone that is very important for many body functions. Research shows that genetics can contribute to this condition. In some cases, men inherit specific genes or variations that affect how well their bodies make testosterone. For example, Klinefelter syndrome is a well-known genetic condition where a man has an extra X chromosome, which often leads to lower testosterone levels. Studies using large groups of people have found markers in the genes that seem to be connected with low testosterone. This means that if your family has a history of low testosterone or related conditions, you might be at a higher risk. However, it’s important to know that while genetics is a key factor, many other things like age, weight, and overall health also influence testosterone levels. If you’re worried about low testosterone, discussing your concerns with a doctor can help determine if genetic factors may be playing a role and what steps you can take next.

(References)

  • Fantus RJ, Na R, Wei J, Shi Z, Resurreccion WK, Halpern JA, Franco O, Hayward SW, Isaacs WB, Zheng SL, Xu J, Helfand BT. Genetic Susceptibility for Low Testosterone in Men and Its Implications in Biology and Screening: Data from the UK Biobank. Eur Urol Open Sci. 2021 May 25;29:36-46. doi: 10.1016/j.euros.2021.04.010. PMID: 34337532; PMCID: PMC8317803.

  • Millar AC, Faghfoury H, Bieniek JM. Genetics of hypogonadotropic hypogonadism. Transl Androl Urol. 2021 Mar;10(3):1401-1409. doi: 10.21037/tau.2020.03.33. PMID: 33850776; PMCID: PMC8039576.

  • Los E, Leslie SW, Ford GA. Klinefelter Syndrome. [Updated 2023 Nov 12]. In: StatPearls [Internet]

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