How can multiple myeloma cause lightheadedness upon standing?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Multiple myeloma can cause lightheadedness when standing, a symptom known as orthostatic hypotension. This occurs when the body struggles to regulate blood pressure during position changes, often due to nerve damage (autonomic neuropathy) linked to the disease or its treatments. Amyloid deposits, anemia, and dehydration common in myeloma patients can also contribute to these dizzy spells.

Because lightheadedness has many possible causes—ranging from mild dehydration to serious conditions like multiple myeloma—it's important not to guess. Understanding your symptoms early can help you make informed decisions about seeing a doctor and what tests to request. Take a free, instant, online symptom check to better understand what may be behind your dizziness and confidently plan your next steps.

Reviewed for medical accuracy: 07/14/2026

Important Next Steps

Learn if standing lightheadedness needs urgent care Discover likely causes of your lightheadedness Find out if it could be multiple myeloma See if your symptoms suggest anemia Find OTC options for lightheadedness relief Find a doctor for dizziness and blood disorders Understand home remedies for standing lightheadedness

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Explanation

Multiple myeloma is a type of cancer that affects plasma cells in the bone marrow. One of the symptoms people might experience is feeling lightheaded, especially when standing up. This can happen because multiple myeloma can cause problems with the nerves that help control blood pressure.

How it Happens:

Nerve Damage: The disease can affect nerves that help control how blood vessels tighten or relax, leading to issues with blood pressure.
Blood Pressure Drops: When you stand up, your blood pressure might not adjust quickly enough, causing you to feel dizzy or lightheaded.

Why It's Important:

Safety: Feeling lightheaded can increase the risk of falling, which can be dangerous.
Management: Understanding this symptom can help in managing the condition better.

The management of these symptoms often involves addressing the nerve issues and ensuring blood pressure is maintained properly. If you're experiencing lightheadedness or other concerning symptoms, consider using a free symptom checker to help identify potential causes and determine when to seek medical care. Always consult healthcare providers for proper diagnosis and treatment plans.

(References)

Biaggioni I. (2014). New developments in the management of neurogenic .... Current cardiology reports, 25303896.
Gibson JS, Hunter CB, & Hewitt LA. (2020). A Call to Action: The Role of Healthcare Providers in .... Neurology and therapy, 32720118.
Claassen DO, Adler CH, Hewitt LA, & Gibbons C. (2018). Characterization of the symptoms of neurogenic orthostatic .... BMC neurology, 30144800.

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