Published on: 7/22/2025
Why do some people have lingering Lyme disease symptoms?
Some people have lingering symptoms after Lyme disease because their bodies react differently to the bacteria, causing ongoing issues even after treatment.
Explanation
After Lyme disease treatment, some people continue to have symptoms like tiredness, pain, or trouble thinking. This is sometimes called Post-treatment Lyme Disease Syndrome (PTLDS). Researchers are not completely sure why this happens, but they have some ideas.
Immune Response: Some people's immune systems might keep reacting to the bacteria even after it is gone, causing inflammation and symptoms.
Bacterial Remnants: Sometimes, tiny pieces of the bacteria might stay in the body and keep causing problems.
Nervous System Changes: The bacteria might affect the brain or nerves, leading to lasting symptoms.
These symptoms can be frustrating, but it is important to talk to a doctor about them. They can help manage the symptoms and offer support. If you feel very sad or worried, you can visit 988lifeline.org for help.
(References)
- Baarsma ME, & Hovius JW. (2024). Persistent Symptoms After Lyme Disease. The Journal of infectious diseases, 39140720.
- Wester KE, Nwokeabia BC, Hassan R, Dunphy T, Osondu M, Wonders C, & Khaja M. (2024). Exploring the Mechanisms of Post-treatment Lyme Disease .... Cureus, 39161484.
- Rebman AW, & Aucott JN. (2020). Post-treatment Lyme Disease as a Model for Persistent .... Frontiers in medicine, 32161761.
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