What are the primary causes of low back pain associated with multiple myeloma?

Low back pain in individuals with multiple myeloma is primarily due to the disease's impact on the bones. Multiple myeloma is a type of cancer that affects plasma cells in the bone marrow. It can lead to bone lesions or damage, particularly in the spine, which is a common site for the disease to manifest.

Causes of Low Back Pain in Multiple Myeloma:

1. Bone Lesions: These are areas where the bone is damaged or destroyed, often leading to pain.
2. Fractures: The weakened bones can fracture more easily, especially in the spine, causing significant pain.
3. Spinal Compression: Sometimes, the weakened bones can lead to compression of the spinal cord or nerves, adding to the pain experienced.

Managing this pain often involves treating the underlying multiple myeloma and addressing the bone damage through medications, physical therapy, or sometimes surgery. It's important for individuals with multiple myeloma experiencing back pain to discuss their symptoms with their healthcare provider for appropriate management.