Published on: 7/4/2025
Which medications are known to cause frequent urination at night?
Certain medications like clozapine and selective serotonin reuptake inhibitors (SSRIs) can cause frequent urination at night, also known as nocturia.
Explanation
Frequent urination at night, called nocturia, can be caused by some medications. Clozapine, which is used for mental health conditions, is one such medication. It can lead to increased nighttime urination. If you or someone you know is experiencing mental health issues, please visit 988lifeline.org for support.
Another group of medications that can cause this problem are Selective Serotonin Reuptake Inhibitors (SSRIs). These are often used to treat depression and anxiety. Some people taking SSRIs may find themselves needing to urinate more often at night.
As people get older, they might also experience more frequent urination due to changes in their bodies or because of other medications they are taking. It is important to talk to a healthcare provider if you notice changes in your urination pattern, especially if it is affecting your sleep or daily life. They can help determine if a medication is causing the issue and discuss possible solutions.
(References)
- Kallas HE, Chintanadilok J, Maruenda J, Donahue JL, & Lowenthal DT. (1999). Treatment of nocturia in the elderly. Drugs & aging, 10641954.
- Tanzer T, Warren N, McMahon L, Barras M, Kisely S, Brooks E, et al. (2022). Treatment strategies for clozapine-induced nocturnal .... CNS spectrums, 35086595.
- Movig KL, Leufkens HG, Belitser SV, Lenderink AW, & Egberts AC. (2002). Selective serotonin reuptake inhibitor-induced urinary .... Pharmacoepidemiology and drug safety, 12138594.
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