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Published on: 11/20/2025
Can certain medications trigger or worsen REM Sleep Behavior Disorder (RBD)?
Some medications, like certain antidepressants, can trigger or worsen REM Sleep Behavior Disorder (RBD).
Wondering why medications affect RBD?
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REM Sleep Behavior Disorder (RBD) is a condition where people act out their dreams while sleeping. Certain medications, especially some antidepressants, can trigger or make RBD worse.
Medications That May Affect RBD:
- Mirtazapine: This is an antidepressant that has been found to induce RBD in some people.
- Other Antidepressants: Research indicates that various antidepressants might increase the risk of RBD.
Understanding RBD:
- What is RBD?: During normal REM sleep, the body is usually still, but in RBD, people might move or talk.
- Why Medications Matter: Some medications affect brain chemicals that control sleep, possibly leading to RBD.
If you or someone you know is experiencing sleep problems or mental health concerns, it's important to talk to a healthcare provider. For immediate mental health support, visit 988lifeline.org.
(References)
- Onofrj M, Luciano AL, Thomas A, Iacono D, & D'Andreamatteo G. (2003). Mirtazapine induces REM sleep behavior disorder (RBD) .... Neurology, 12525729.
- Postuma RB, Gagnon JF, Tuineaig M, Bertrand JA, Latreille V, Desjardins C, & Montplaisir JY. (2013). Antidepressants and REM Sleep Behavior Disorder. Sleep, 24179289.
- Mahowald MW, Schenck CH, & Bornemann MA. (2007). Pathophysiologic mechanisms in REM sleep behavior .... Current neurology and neuroscience reports, 17355839.
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