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Published on: 3/5/2025

Is Memory Loss From Antidepressants Permanent?

Memory loss from antidepressants is usually not permanent. Many people find that any memory issues improve after the medication is stopped or the dose is changed.

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Explanation

Some antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), can cause short-term memory problems in certain individuals. Research shows that many people experience these side effects only while taking the medication, and the memory issues often go away when the treatment is adjusted or stopped. It is important to know that memory loss related to antidepressants is not typically permanent. In older adults, studies have shown mixed results. Some research suggests an association between antidepressant use and an increased risk of dementia, but these findings are influenced by many factors like age and overall health. Sometimes, the depression itself can affect memory, making it harder to decide whether the medication or the depression is causing the memory issues. If you are experiencing memory loss while on an antidepressant, it's important to talk with your healthcare provider. They can evaluate your situation and may adjust your treatment plan to help lessen the memory concerns. Always remember that everyone reacts differently to medications, so your experience might not be the same as others.

(References)

  • Saczynski JS, Rosen AB, McCammon RJ, Zivin K, Andrade SE, Langa KM, Vijan S, Pirraglia PA, Briesacher BA. Antidepressant Use and Cognitive Decline: The Health and Retirement Study. Am J Med. 2015 Jul;128(7):739-46. doi: 10.1016/j.amjmed.2015.01.007. Epub 2015 Jan 30. PMID: 25644319; PMCID: PMC4618694.

  • Schulkens JE, Deckers K, Jenniskens M, Blokland A, Verhey FR, Sobczak S. The effects of selective serotonin reuptake inhibitors on memory functioning in older adults: A systematic literature review. J Psychopharmacol. 2022 May;36(5):578-593. doi: 10.1177/02698811221080462. Epub 2022 Apr 29. PMID: 35486412; PMCID: PMC9112622.

  • Wang C, Gao S, Hendrie HC, Kesterson J, Campbell NL, Shekhar A, Callahan CM. Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia. Alzheimer Dis Assoc Disord. 2016 Apr-Jun;30(2):99-104. doi: 10.1097/WAD.0000000000000103. PMID: 26295747; PMCID: PMC4760914.

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