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Published on: 2/24/2026
Migraine is a neurological disorder, and several key points matter if your migraine will not stop. Nurtec (rimegepant) blocks CGRP to calm the migraine process, can relieve pain within about 2 hours for many, and can also help prevent future attacks when used as prescribed.
See below for medically approved steps that can change next steps in your care, including treating early, avoiding medication overuse, hydrating and resting in a dark quiet room, considering preventive options and non-drug supports, tracking triggers, and knowing when to seek urgent or emergency care such as for status migrainosus lasting over 72 hours.
If you're dealing with a migraine that just won't quit, you're not alone. Migraine is a neurological condition—not "just a bad headache." It can cause throbbing head pain, nausea, light sensitivity, sound sensitivity, and even visual changes. For some people, attacks last hours. For others, they can stretch into days.
The good news: modern treatments like Nurtec (rimegepant) are changing how migraines are treated. And there are clear, medically approved steps you can take to regain control.
Let's walk through what's happening in your body, why Nurtec works, and what else you can do safely and effectively.
Migraines are driven by complex changes in the brain. One key player is a protein called CGRP (calcitonin gene-related peptide). During a migraine attack:
If this process continues unchecked, the migraine can linger or return quickly after temporary relief.
Triggers can include:
When migraines become frequent (15 or more headache days per month), doctors may diagnose chronic migraine, which requires a more structured treatment plan.
Nurtec ODT (rimegepant) is FDA-approved for:
That dual action is part of what makes it unique.
Unlike older migraine medications that constrict blood vessels, Nurtec blocks CGRP receptors. This helps:
Because it does not constrict blood vessels, it may be an option for people who cannot take triptans due to cardiovascular concerns (though your doctor must determine what's safe for you).
Clinical studies have shown that Nurtec can:
It comes as an orally disintegrating tablet (ODT), which dissolves on the tongue—helpful if nausea makes swallowing pills difficult.
You might consider asking your doctor about Nurtec if:
Common side effects are generally mild and may include nausea or stomach discomfort. Serious reactions are rare but possible, including allergic reactions.
Always discuss your full medical history and medication list with your healthcare provider before starting Nurtec.
If your migraine is lingering, here are evidence-based steps doctors recommend:
Migraine medications work best when taken at the first sign of symptoms.
Using medications too frequently (more than 10–15 days per month depending on the medication) can cause medication-overuse headache, which makes migraines harder to control.
While hydration won't cure a migraine, dehydration can worsen it.
Sleep can help reset the nervous system, but too much daytime sleep may disrupt nighttime rest.
If you experience:
Your doctor may recommend preventive treatment.
Options include:
Preventive therapy aims to reduce frequency and severity—not just treat attacks.
Keeping a migraine diary can help you spot patterns.
Track:
If you're unsure whether your symptoms align with migraine patterns, you can use a free AI-powered migraine symptom checker to assess your symptoms and get personalized insights before your next doctor's visit.
Evidence supports several non-medication approaches:
Lifestyle strategies are not "alternative medicine"—they are part of standard migraine management.
Most migraines are not life-threatening. However, certain symptoms require immediate medical care.
Seek emergency attention if you experience:
These could signal conditions such as stroke, meningitis, or bleeding in the brain.
Do not ignore these symptoms.
A migraine lasting more than 72 hours is called status migrainosus. This often requires medical treatment such as:
If your attack is ongoing and not responding to home treatment, it's appropriate to seek urgent care.
Migraines are a neurological disorder—not a sign of weakness, stress intolerance, or poor pain tolerance.
Nurtec works by targeting CGRP, a key driver of migraine pain. It can treat attacks and, when prescribed appropriately, help prevent future ones. For many people, this represents a significant advancement over older therapies.
But medication is just one piece of the puzzle.
The most effective migraine plans combine:
If your migraine won't stop—or keeps coming back—don't try to push through it alone.
While online information is helpful, it cannot replace medical evaluation. If your migraines are:
You should speak to a doctor promptly.
And if you experience any symptoms that could be life-threatening, seek emergency care immediately.
Migraines are treatable. With the right combination of therapies—including options like Nurtec—many people achieve meaningful relief and regain control of their lives.
(References)
* Croop R, Goadsby PJ, Kudrow D, et al. Oral rimegepant for the acute treatment of migraine: a phase 2/3 double-blind, randomized, placebo-controlled trial. Lancet. 2019 Jun 22;393(10189):2418-2426. doi: 10.1016/S0140-6736(19)30700-9. Epub 2019 May 14. PMID: 31103348.
* Croop R, Lipton RB, Kudrow D, et al. Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial. Lancet. 2021 Jan 9;397(10268):51-60. doi: 10.1016/S0140-6736(20)32545-4. Epub 2020 Dec 15. PMID: 33333032.
* Edvinsson L. The CGRP Pathway in Migraine. Headache. 2018 Mar;58 Suppl 1:33-40. doi: 10.1111/head.13241. Epub 2018 Jan 25. PMID: 29372551.
* Lipton RB, Croop R, Goadsby PJ. Rimegepant and other CGRP Receptor Antagonists for the Acute and Preventive Treatment of Migraine. Neurol Clin. 2022 Feb;40(1):15-32. doi: 10.1016/j.ncl.2021.08.002. Epub 2021 Oct 16. PMID: 34794692.
* Ashina M, Sacco S, Holland S, et al. Evidenced-based review and recommendations for migraine prevention: European Headache Federation (EHF) consensus on the use of rimegepant. J Headache Pain. 2023 Mar 1;24(1):21. doi: 10.1186/s10194-023-01552-w. PMID: 36859702. PMCID: PMC9978711.
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