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Published on: 2/10/2026
Milk thistle may support liver cell protection, medication metabolism, antioxidant defenses, and mild digestive comfort in women 65+, with early evidence for modest blood sugar and cholesterol benefits, but it is not a cure and should complement medical care. There are several factors to consider; see the key safety and how to details below and talk with your clinician first, especially if you take multiple medications or have liver related symptoms.
As women move into their mid‑60s and beyond, the body changes in ways that can affect liver health, energy, digestion, and how medications are processed. One herbal supplement that often comes up in conversations about healthy aging is Milk thistle. Used for centuries and studied in modern medicine, Milk thistle has a long-standing reputation for supporting the liver and overall wellness—especially in older adults.
This article explains what Milk thistle is, how it may help women aged 65+, what the science actually says, and what to consider before using it.
Milk thistle (Silybum marianum) is a flowering plant native to the Mediterranean region. The active compound in Milk thistle is silymarin, a group of plant chemicals known for antioxidant and anti‑inflammatory effects.
Silymarin is believed to:
Because the liver plays a central role in aging, digestion, hormone balance, and medication metabolism, Milk thistle has drawn special interest among women over 65.
The liver works quietly in the background, but it is one of the hardest‑working organs in the body. As we age:
For women 65+, this means liver support becomes more important—not because something is "wrong," but because the liver is doing more work with fewer reserves.
Milk thistle is often explored as a supportive option, not a cure.
The most well‑researched benefit of Milk thistle is liver protection.
Studies suggest silymarin may help:
This can be helpful for women who:
Milk thistle is not a treatment for serious liver disease, but it may support liver resilience over time.
Women over 65 are more likely to take multiple medications. The liver is responsible for breaking these down safely.
Milk thistle may help by:
However, Milk thistle can interact with certain medications, so medical guidance is essential (more on this below).
Aging is closely linked to oxidative stress—cell damage caused by free radicals.
Milk thistle contains antioxidants that may:
While this won't "reverse aging," it may help the body age more smoothly.
The liver and digestion are closely connected through bile production.
Some women report that Milk thistle helps with:
These effects are usually subtle and develop over time, not overnight.
Early research suggests Milk thistle may have modest benefits for:
This may be relevant for women managing type 2 diabetes or metabolic syndrome, but the evidence is still developing. Milk thistle should never replace prescribed treatments.
Milk thistle is sometimes discussed in connection with liver conditions such as hepatitis or fatty liver disease. It's important to be clear and balanced:
If you're experiencing symptoms like fatigue, yellowing of the skin or eyes, dark urine, nausea, or abdominal discomfort, use Ubie's free AI-powered Acute Hepatitis symptom checker to help identify whether your symptoms may be related to liver inflammation and understand when to seek medical attention.
Milk thistle is generally considered well‑tolerated, but "natural" does not always mean "risk‑free."
These often improve when taken with food.
Women 65+ should be especially cautious if they:
Milk thistle can affect how certain drugs are metabolized. This doesn't mean it's unsafe—but it does mean professional guidance matters.
Not all Milk thistle products are equal.
Look for:
Avoid products that make bold claims about "curing" liver disease. That's a red flag.
Many studies use doses ranging from 200–400 mg of silymarin per day, often divided into two doses.
However:
Always confirm dosing with a healthcare professional.
Milk thistle may not be suitable if you:
If symptoms feel sudden, severe, or worsening, don't rely on supplements alone.
Milk thistle may offer gentle, meaningful support for liver health and healthy aging in women over 65. Its antioxidant and liver‑protective properties are supported by decades of research, but it works best as part of a broader health plan—not as a stand‑alone solution.
It is most appropriate for:
It is not a substitute for medical care, testing, or treatment.
If you're concerned about potential liver issues, it's worth taking a few minutes to check your symptoms using a trusted resource—Ubie's Acute Hepatitis symptom checker can help you understand if your concerns warrant a conversation with your doctor.
Most importantly, speak to a doctor before starting Milk thistle—especially if you have a chronic condition, take prescription medications, or notice symptoms that could be serious or life‑threatening. Early, informed conversations can make a real difference in long‑term health.
(References)
* Kumar A, Singh A, Singh A, et al. Silymarin: A comprehensive review of its hepatoprotective potential. Phytother Res. 2020 Aug;34(8):1753-1768. doi: 10.1002/ptr.6672. Epub 2020 May 16. PMID: 32419409.
* Soliman A, El-Said HM, Attia N, et al. Targeting Liver Fibrosis: Role of Silymarin. Front Pharmacol. 2021 Oct 7;12:756383. doi: 10.3389/fphar.2021.756383. PMID: 34685376; PMCID: PMC8529249.
* Hadar R, Al-Rifai H, Rida A, et al. Antioxidant and anti-inflammatory effects of silymarin in chronic diseases. Front Pharmacol. 2022 Jul 26;13:951475. doi: 10.3389/fphar.2022.951475. PMID: 35957016; PMCID: PMC9361730.
* Rauf A, Khan M, Khan H, et al. Silymarin as a potential candidate to ameliorate aging-related diseases. Phytomedicine. 2023 Apr;110:154625. doi: 10.1016/j.phymed.2023.154625. Epub 2023 Feb 28. PMID: 37025217.
* Yao J, Duan Y, Zhang Z, et al. Clinical Efficacy and Safety of Silymarin in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2021 Jul 15;2021:6644026. doi: 10.1155/2021/6644026. PMID: 34283935; PMCID: PMC8298018.
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