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Published on: 2/10/2026

Milk Thistle for Women 65+: Vital Benefits for Liver & Aging Health

Milk thistle may support liver cell protection, medication metabolism, antioxidant defenses, and mild digestive comfort in women 65+, with early evidence for modest blood sugar and cholesterol benefits, but it is not a cure and should complement medical care. There are several factors to consider; see the key safety and how to details below and talk with your clinician first, especially if you take multiple medications or have liver related symptoms.

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Milk Thistle for Women 65+: Vital Benefits for Liver & Aging Health

As women move into their mid‑60s and beyond, the body changes in ways that can affect liver health, energy, digestion, and how medications are processed. One herbal supplement that often comes up in conversations about healthy aging is Milk thistle. Used for centuries and studied in modern medicine, Milk thistle has a long-standing reputation for supporting the liver and overall wellness—especially in older adults.

This article explains what Milk thistle is, how it may help women aged 65+, what the science actually says, and what to consider before using it.


What Is Milk Thistle?

Milk thistle (Silybum marianum) is a flowering plant native to the Mediterranean region. The active compound in Milk thistle is silymarin, a group of plant chemicals known for antioxidant and anti‑inflammatory effects.

Silymarin is believed to:

  • Protect liver cells from damage
  • Support the liver's natural detox processes
  • Help reduce inflammation and oxidative stress

Because the liver plays a central role in aging, digestion, hormone balance, and medication metabolism, Milk thistle has drawn special interest among women over 65.


Why Liver Health Matters More After 65

The liver works quietly in the background, but it is one of the hardest‑working organs in the body. As we age:

  • Liver blood flow slowly decreases
  • The liver may regenerate more slowly
  • Medication processing can take longer
  • Long‑term exposure to alcohol, medications, or environmental toxins adds up

For women 65+, this means liver support becomes more important—not because something is "wrong," but because the liver is doing more work with fewer reserves.

Milk thistle is often explored as a supportive option, not a cure.


Potential Benefits of Milk Thistle for Women 65+

1. Liver Cell Protection

The most well‑researched benefit of Milk thistle is liver protection.

Studies suggest silymarin may help:

  • Stabilize liver cell membranes
  • Reduce damage from oxidative stress
  • Support regeneration of liver tissue

This can be helpful for women who:

  • Take long‑term prescription medications
  • Have a history of fatty liver disease
  • Have had past liver inflammation

Milk thistle is not a treatment for serious liver disease, but it may support liver resilience over time.


2. Support for Medication Metabolism

Women over 65 are more likely to take multiple medications. The liver is responsible for breaking these down safely.

Milk thistle may help by:

  • Supporting enzyme balance in the liver
  • Reducing oxidative stress caused by medication processing

However, Milk thistle can interact with certain medications, so medical guidance is essential (more on this below).


3. Antioxidant Support and Healthy Aging

Aging is closely linked to oxidative stress—cell damage caused by free radicals.

Milk thistle contains antioxidants that may:

  • Help protect cells from age‑related damage
  • Support immune system balance
  • Contribute to overall vitality

While this won't "reverse aging," it may help the body age more smoothly.


4. Digestive Comfort

The liver and digestion are closely connected through bile production.

Some women report that Milk thistle helps with:

  • Mild bloating
  • Fat digestion
  • General digestive comfort

These effects are usually subtle and develop over time, not overnight.


5. Blood Sugar and Cholesterol Support (Emerging Evidence)

Early research suggests Milk thistle may have modest benefits for:

  • Blood sugar balance
  • Cholesterol metabolism

This may be relevant for women managing type 2 diabetes or metabolic syndrome, but the evidence is still developing. Milk thistle should never replace prescribed treatments.


Milk Thistle and Liver Conditions: A Realistic View

Milk thistle is sometimes discussed in connection with liver conditions such as hepatitis or fatty liver disease. It's important to be clear and balanced:

  • Milk thistle does not cure hepatitis
  • It does not replace medical treatment
  • It may support liver health alongside proper care

If you're experiencing symptoms like fatigue, yellowing of the skin or eyes, dark urine, nausea, or abdominal discomfort, use Ubie's free AI-powered Acute Hepatitis symptom checker to help identify whether your symptoms may be related to liver inflammation and understand when to seek medical attention.


Is Milk Thistle Safe for Women 65+?

Milk thistle is generally considered well‑tolerated, but "natural" does not always mean "risk‑free."

Common Side Effects (Usually Mild)

  • Upset stomach
  • Gas or bloating
  • Mild headache

These often improve when taken with food.

Important Safety Considerations

Women 65+ should be especially cautious if they:

  • Take blood thinners
  • Take diabetes medications
  • Use hormone‑related therapies
  • Have known liver disease

Milk thistle can affect how certain drugs are metabolized. This doesn't mean it's unsafe—but it does mean professional guidance matters.


How to Choose a Quality Milk Thistle Supplement

Not all Milk thistle products are equal.

Look for:

  • Standardized silymarin content (typically 70–80%)
  • Clear labeling of dosage
  • Third‑party quality testing
  • Minimal fillers or artificial additives

Avoid products that make bold claims about "curing" liver disease. That's a red flag.


Typical Dosage Guidance (General Information)

Many studies use doses ranging from 200–400 mg of silymarin per day, often divided into two doses.

However:

  • There is no one‑size‑fits‑all dose
  • Age, health conditions, and medications matter
  • Starting low and increasing gradually is often recommended

Always confirm dosing with a healthcare professional.


When Milk Thistle May Not Be Appropriate

Milk thistle may not be suitable if you:

  • Have hormone‑sensitive conditions
  • Are allergic to plants in the daisy family
  • Are managing a serious or acute liver condition without medical care

If symptoms feel sudden, severe, or worsening, don't rely on supplements alone.


The Bottom Line for Women 65+

Milk thistle may offer gentle, meaningful support for liver health and healthy aging in women over 65. Its antioxidant and liver‑protective properties are supported by decades of research, but it works best as part of a broader health plan—not as a stand‑alone solution.

It is most appropriate for:

  • Long‑term liver support
  • Women managing multiple medications
  • Those focused on healthy aging and prevention

It is not a substitute for medical care, testing, or treatment.


A Final, Important Reminder

If you're concerned about potential liver issues, it's worth taking a few minutes to check your symptoms using a trusted resource—Ubie's Acute Hepatitis symptom checker can help you understand if your concerns warrant a conversation with your doctor.

Most importantly, speak to a doctor before starting Milk thistle—especially if you have a chronic condition, take prescription medications, or notice symptoms that could be serious or life‑threatening. Early, informed conversations can make a real difference in long‑term health.

(References)

  • * Kumar A, Singh A, Singh A, et al. Silymarin: A comprehensive review of its hepatoprotective potential. Phytother Res. 2020 Aug;34(8):1753-1768. doi: 10.1002/ptr.6672. Epub 2020 May 16. PMID: 32419409.

  • * Soliman A, El-Said HM, Attia N, et al. Targeting Liver Fibrosis: Role of Silymarin. Front Pharmacol. 2021 Oct 7;12:756383. doi: 10.3389/fphar.2021.756383. PMID: 34685376; PMCID: PMC8529249.

  • * Hadar R, Al-Rifai H, Rida A, et al. Antioxidant and anti-inflammatory effects of silymarin in chronic diseases. Front Pharmacol. 2022 Jul 26;13:951475. doi: 10.3389/fphar.2022.951475. PMID: 35957016; PMCID: PMC9361730.

  • * Rauf A, Khan M, Khan H, et al. Silymarin as a potential candidate to ameliorate aging-related diseases. Phytomedicine. 2023 Apr;110:154625. doi: 10.1016/j.phymed.2023.154625. Epub 2023 Feb 28. PMID: 37025217.

  • * Yao J, Duan Y, Zhang Z, et al. Clinical Efficacy and Safety of Silymarin in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2021 Jul 15;2021:6644026. doi: 10.1155/2021/6644026. PMID: 34283935; PMCID: PMC8298018.

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