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Published on: 2/24/2026
There are several factors to consider when a skin sore will not heal: MRSA is possible if the area is red, swollen, warm, rapidly enlarging, painful, and draining pus, sometimes with fever, but only a clinician exam and a wound culture can confirm it.
Next steps include prompt medical evaluation for possible drainage and the right antibiotic, keeping the wound clean and covered, and preventing spread with good hygiene; see the complete guidance below for urgent red flags, who is at higher risk, and how look-alikes like cellulitis can change the care you need.
If you have a skin sore that isn't healing, keeps getting worse, or keeps coming back, it's natural to wonder: Is this MRSA?
MRSA is a common concern when skin infections don't improve as expected. While not every stubborn wound is MRSA, some are—and knowing the difference can help you take the right next steps.
Let's break down what MRSA is, why some skin infections won't heal, what warning signs to look for, and what you should do next.
MRSA stands for Methicillin-Resistant Staphylococcus aureus. It's a type of staph bacteria that has become resistant to several common antibiotics.
Staph bacteria normally live on the skin and in the nose of many healthy people without causing harm. Problems happen when bacteria enter the body through:
Most staph infections are mild and treatable. MRSA, however, is harder to treat because common antibiotics may not work against it.
There are two main types:
Not all slow-healing wounds are MRSA. Several factors can delay healing:
If bacteria remain active in the wound, your immune system keeps fighting, preventing proper healing.
Conditions like diabetes or vascular disease reduce blood flow, which slows healing.
Picking, squeezing, or rubbing a sore can reopen the wound.
Stress, illness, diabetes, or certain medications can reduce your body's ability to fight infection.
Using the wrong antibiotic—or stopping antibiotics too early—can allow resistant bacteria like MRSA to survive.
If your skin infection is not improving after a few days of proper care, or seems to be worsening, it's time to consider medical evaluation.
MRSA skin infections often look like common skin problems at first. They may resemble:
However, MRSA infections often develop certain characteristics:
The area may start small but quickly become more painful or filled with pus.
One important note: MRSA cannot be diagnosed by appearance alone. A doctor may need to take a sample (culture) from the wound to confirm.
Sometimes what looks like a stubborn skin infection may actually be cellulitis or erysipelas, which are deeper skin infections.
Cellulitis symptoms often include:
Unlike a boil or abscess, cellulitis usually doesn't form a visible pocket of pus.
If you're experiencing spreading redness, warmth, and swelling that may indicate a deeper skin infection, you can use a free Cellulitis / Erysipelas symptom checker to help assess your symptoms and determine how urgently you need medical attention.
This can help you decide how urgently you need medical care—but it should never replace seeing a doctor if symptoms are worsening.
Many MRSA skin infections are treatable and do not become life-threatening. However, MRSA can become serious if:
In rare cases, MRSA can enter the bloodstream and cause severe illness. That's why early treatment matters.
This is not meant to scare you—but it is important to take persistent skin infections seriously.
If you suspect MRSA or any worsening skin infection, here are the appropriate next steps:
A healthcare professional can:
Do not attempt to squeeze or drain the lesion yourself. This can spread infection.
If antibiotics are prescribed:
Stopping early is one reason antibiotic resistance develops.
MRSA spreads through direct contact.
To reduce risk:
Seek urgent care if you notice:
Some people are more likely to develop MRSA infections:
If you fall into one of these groups and develop a non-healing skin lesion, it's especially important to get evaluated.
Small abscesses sometimes drain and improve on their own. However:
It's not wise to "wait it out" if the infection is painful, growing, or not improving within a few days.
Prevention focuses on hygiene and skin protection:
If you experience repeated MRSA infections, your doctor may discuss decolonization strategies (such as medicated nasal ointment or antiseptic washes).
A skin sore that won't heal doesn't automatically mean MRSA, but it should not be ignored.
Key takeaways:
If your skin infection is worsening, spreading, extremely painful, or associated with fever, seek medical care promptly.
And if you're unsure whether your symptoms align with a deeper skin infection like Cellulitis / Erysipelas, consider using a symptom checker as a first step to understanding your condition before seeking professional medical advice.
Most importantly: Speak to a doctor about any infection that could be serious, life-threatening, or not improving. Early evaluation and proper treatment make a major difference.
Being cautious isn't overreacting—it's smart healthcare.
(References)
* Spellberg, B., & J. (2015). Diagnosis and management of skin and soft tissue infections caused by MRSA. *Infectious Disease Clinics of North America*, *29*(3), 517-532.
* O'Donnell, K. L., & Boyle, K. (2020). Management of non-healing wounds: A comprehensive review. *Advances in Skin & Wound Care*, *33*(9), 466-476.
* Wozniak, P. S., & O'Horo, J. C. (2021). Management of Skin and Soft Tissue Infections. *Infectious Disease Clinics of North America*, *35*(2), 481-499.
* Jenkins, K., & Moran, G. J. (2018). Recurrent skin and soft tissue infections: an update on diagnosis and management. *Current Opinion in Infectious Diseases*, *31*(4), 304-309.
* David, M. Z., & Cadman, E. T. (2019). Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin and soft tissue infections: a concise review. *Clinical Microbiology Reviews*, *32*(4), e00057-19.
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