Published on: 7/24/2025
Is muscle loss a known side effect of GLP-1 drugs?
GLP-1 drugs can lead to a decrease in muscle mass, which is a side effect to consider.
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Explanation
GLP-1 drugs, often used for weight management and diabetes, have been studied for their effects on muscle mass. Research indicates that these medications can lead to a reduction in lean body mass, which includes muscle.
Studies have discussed these changes, suggesting a decrease in muscle mass over time. Research also highlights that GLP-1 receptor agonists can affect muscle, potentially leading to muscle loss, which is important for patients to be aware of. Further investigations into the relationship between GLP-1 drugs and muscle mass support the idea that muscle loss can occur.
Understanding these effects is important for individuals taking GLP-1 drugs, as maintaining muscle mass is crucial for overall health. If you are concerned about muscle loss, it is advisable to discuss this with your healthcare provider.
(References)
- Neeland IJ, Linge J, & Birkenfeld AL. (2024). Changes in lean body mass with glucagon-like peptide-1- .... Diabetes, obesity & metabolism, 38937282.
- Old VJ, Davies MJ, Papamargaritis D, Choudhary P, & Watson EL. (2025). The Effects of Glucagon-Like Peptide-1 Receptor Agonists .... Journal of cachexia, sarcopenia and muscle, 39815782.
- Linge J, Birkenfeld AL, & Neeland IJ. (2024). Muscle Mass and Glucagon-Like Peptide-1 Receptor .... Circulation, 39401279.
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