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Published on: 7/24/2025

How prevalent is muscle loss among GLP-1 users?

Muscle loss can occur in people using GLP-1 medications like semaglutide, especially if they lose weight quickly without exercise.

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Explanation

GLP-1 medications, such as semaglutide, are often used for weight loss and diabetes management. According to the studies, some users experience a decrease in muscle mass, particularly when they lose weight rapidly.

Key Points:

  1. Lean Mass Changes: A study found that while GLP-1 helps with weight loss, it can also lead to muscle loss, especially if the weight loss is fast.
  2. Semaglutide Effects: Another review highlighted that semaglutide users might lose some muscle mass, but this varies among individuals.
  3. Diet and Exercise: Maintaining muscle mass during weight loss is possible with a balanced diet and regular exercise, as suggested by research on nutrition and physical activity.

To minimize muscle loss, it's important to combine GLP-1 therapy with healthy eating and physical activity. This approach helps preserve muscle while benefiting from the weight loss effects of the medication.

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