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Published on: 2/25/2026

Persistent Muscle Pain? Why Lactic Acid Builds Up & Medical Next Steps

Persistent muscle pain is rarely just lactic acid; lactate rises during intense exercise when oxygen falls short and clears within 30 to 60 minutes, while soreness days later usually comes from DOMS, overuse, electrolyte issues, infections, medications, or chronic conditions. There are several factors to consider, so see below to understand more.

Seek urgent care for red flags like rapid breathing, confusion, severe weakness, chest pain, or dark urine that could signal lactic acidosis or rhabdomyolysis, and see a doctor if pain lasts over a week or limits daily life; below you will find specific symptoms to watch for, self care tips, ways to reduce lactate during workouts, and the tests clinicians use to guide next steps.

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Explanation

Persistent Muscle Pain? Why Lactic Acid Builds Up & Medical Next Steps

Persistent muscle pain can be frustrating, especially when you're told it's "just lactic acid." While lactic acid does play a role in muscle fatigue during intense activity, it's often misunderstood — and it's rarely the cause of long-lasting muscle pain.

If you're dealing with ongoing soreness, stiffness, or muscle aches (also known as myalgia), it's important to understand what's really happening in your body and when it's time to seek medical advice.


What Is Lactic Acid?

Lactic acid is a substance your body produces when it breaks down glucose (sugar) for energy without enough oxygen available. This typically happens during:

  • High-intensity exercise (sprinting, heavy lifting)
  • Sudden bursts of physical activity
  • Situations where muscles are overworked

Under these conditions, your body switches to a process called anaerobic metabolism, which results in lactate production. Lactate and hydrogen ions accumulate temporarily in muscle tissue.

Important clarification:

Modern research shows that lactic acid itself is not the main cause of muscle soreness the next day. In fact:

  • Lactate levels return to normal within about 30–60 minutes after exercise.
  • Delayed onset muscle soreness (DOMS) that appears 24–72 hours later is caused by microscopic muscle fiber damage, not lingering lactic acid.

Why Does Lactic Acid Build Up?

Lactic acid builds up when oxygen delivery to muscles can't keep up with energy demands. Common triggers include:

  • Intense or unfamiliar exercise
  • Sudden increase in workout intensity
  • Poor conditioning
  • Certain medical conditions affecting oxygen delivery

In most healthy people, this buildup is temporary and normal. Your liver and other tissues recycle lactate efficiently once activity slows.

However, in rare cases, excessive lactate production or reduced clearance can lead to lactic acidosis, a serious medical condition. This is not the same as everyday exercise-related muscle fatigue.


When Muscle Pain Isn't Just Lactic Acid

If your muscle pain lasts more than a few days, spreads, or occurs without intense exercise, lactic acid is unlikely to be the cause.

Persistent muscle pain may be related to:

1. Delayed Onset Muscle Soreness (DOMS)

  • Begins 12–24 hours after exercise
  • Peaks at 24–72 hours
  • Improves within a few days

This is due to microscopic muscle injury and inflammation — not lactic acid.

2. Overuse Injuries

  • Repetitive strain
  • Poor form during exercise
  • Insufficient recovery time

3. Dehydration or Electrolyte Imbalance

Low levels of sodium, potassium, or magnesium can contribute to muscle cramping and soreness.

4. Viral Infections

The flu and other viral illnesses often cause widespread muscle aches.

5. Medication Side Effects

Certain medications, particularly statins used to lower cholesterol, may cause muscle pain in some individuals.

6. Chronic Conditions

  • Fibromyalgia
  • Autoimmune diseases
  • Thyroid disorders
  • Chronic fatigue syndrome

If your pain is ongoing, unexplained, or worsening, it's worth investigating further with a professional evaluation or using an AI-powered Myalgia (Muscle Pain) symptom checker to help identify potential causes and determine your next steps.


What Does Lactic Acidosis Feel Like?

Unlike normal exercise-related lactic acid buildup, lactic acidosis is a medical emergency.

It may cause:

  • Rapid breathing
  • Severe weakness
  • Nausea or vomiting
  • Abdominal pain
  • Confusion
  • Irregular heartbeat

Lactic acidosis can occur due to:

  • Severe infections (sepsis)
  • Heart failure
  • Lung disease
  • Uncontrolled diabetes
  • Kidney or liver failure
  • Certain medications (including metformin in rare cases)

If you experience these symptoms — especially with shortness of breath or confusion — seek emergency medical care immediately.


Why Persistent Muscle Pain Shouldn't Be Ignored

Occasional soreness is normal. Persistent muscle pain is not something to dismiss.

See a doctor if you notice:

  • Pain lasting longer than one week without improvement
  • Muscle weakness
  • Dark-colored urine (possible muscle breakdown)
  • Swelling or redness
  • Fever with muscle pain
  • Pain interfering with daily activities
  • Pain after starting a new medication

In rare cases, severe muscle breakdown called rhabdomyolysis can occur. This condition requires urgent medical treatment and may cause:

  • Severe muscle pain
  • Weakness
  • Dark brown or cola-colored urine

How Doctors Evaluate Muscle Pain

If you speak to a doctor about persistent muscle pain, they may:

  • Review your exercise habits
  • Ask about recent illnesses
  • Review medications
  • Check hydration status
  • Order blood tests

Common lab tests may include:

  • Creatine kinase (CK) to assess muscle breakdown
  • Electrolyte levels
  • Thyroid function tests
  • Kidney and liver function tests
  • Inflammatory markers

These tests help rule out serious causes and identify underlying conditions.


How to Reduce Lactic Acid Buildup During Exercise

While lactic acid doesn't cause long-term soreness, you can reduce uncomfortable buildup during workouts by:

  • Gradually increasing exercise intensity
  • Warming up properly
  • Staying hydrated
  • Improving overall cardiovascular fitness
  • Allowing recovery time between sessions
  • Practicing controlled breathing

Regular training improves your body's ability to clear lactate efficiently.


Safe Ways to Manage Muscle Pain

For non-serious muscle pain, you can try:

  • Rest and gradual return to activity
  • Gentle stretching
  • Light movement (walking, yoga)
  • Ice for acute soreness
  • Heat for stiffness
  • Over-the-counter pain relievers (as directed)
  • Massage therapy

Avoid pushing through severe pain. Pain is a signal, not something to ignore.


The Bottom Line About Lactic Acid

Here's what's important to understand:

  • Lactic acid buildup is temporary and normal during intense exercise.
  • It does not cause muscle soreness days later.
  • Persistent muscle pain usually has another cause.
  • Serious lactic acidosis is rare but requires immediate medical attention.

If your muscle pain is mild and related to recent activity, it will likely improve within a few days. But if it's ongoing, unexplained, or severe, don't assume it's just lactic acid.

Getting a clear picture of your symptoms through a free Myalgia (Muscle Pain) assessment can help you understand what might be causing your discomfort and whether you should see a doctor.

Most importantly, speak to a doctor if:

  • Your symptoms are worsening
  • You have weakness or dark urine
  • You feel short of breath
  • You develop confusion or chest pain
  • The pain is interfering with your normal life

Muscle pain is common — but persistent pain deserves attention. Getting clarity early can help you recover faster and rule out serious conditions.

(References)

  • * Voermans NC, van Alfen N, de Groot IJM. Metabolic Myopathies. Neuromuscular Disorders. 2017 Mar;27(3):214-222.

  • * Maes M, Mihaylova I, Leunis JC. Chronic fatigue syndrome and fibromyalgia are characterised by a breakdown of cellular energy production evidenced by reduced ATP/ADP ratios and an upregulation of the AMPK pathway. Mol Neurobiol. 2016 Oct;53(8):5410-23.

  • * DiMauro S, Garone C, Hirano M. Metabolic myopathies. Handb Clin Neurol. 2018;156:599-623.

  • * San Juan D, Garcia-Villalon L, Monroy M. Hyperlactatemia: causes, clinical manifestations, diagnosis, and treatment. Am J Health Syst Pharm. 2020 Jan 22;77(3):189-198.

  • * Parikh S, Goldstein A, Karaa A, Koenig MK, Ng YS, Saneto RP, Woung P, Zolkipli-Cunningham Z, Karaa Z. Diagnosis and Management of Mitochondrial Disease: A Consensus Statement from the Mitochondrial Medicine Society. Genet Med. 2017 Dec;19(12):1283-1291.

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