What should I do when I test negative for STDs but still have testicle pain?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Testicle pain with negative STD test results is not uncommon and can point to several non-infectious causes. Follow-up with a doctor is essential to rule out conditions such as varicocele (enlarged veins in the scrotum), testicular torsion, epididymitis, hydrocele, inguinal hernia, or reduced blood flow. Your provider may recommend a scrotal ultrasound, urinalysis, or imaging to identify the underlying issue and guide a targeted treatment plan.

Because testicle pain can range from mild to a medical emergency, understanding your symptoms early is critical. A free, instant, online symptom check can help you narrow down possible causes, gauge urgency, and prepare for your next conversation with a healthcare provider—so you can take the right next step with confidence.

Reviewed for medical accuracy: 07/15/2026

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Explanation

Sometimes, testicular pain can be caused by issues other than infections that are checked with STD tests. Varicoceles, hernias, and even back problems can cause testicular pain. Sometimes, intermittent twisting of the blood vessels to the testicle (called torsion) can cause sudden pain; this is a medical emergency.

It is best to work with your doctor to look further into these other health issues. If you're experiencing testicular pain and want to better understand your symptoms before your appointment, try Ubie's free AI symptom checker to help identify possible causes. Your provider will likely perform a physical exam and may order imaging studies of the scrotum. They may advise treatments like pain relievers, scrotal support, or even physical therapy if needed. Remember, following up with your healthcare provider can help you find the right treatment to relieve your pain.

(References)

Tanner R, Twomey M, Maher MM, Fitzgerald E, O'Connor J. A Rare Cause of Testicular Pain: Thrombosis of the Pampiniform Plexus. Ir Med J. 2016 Jan;109(1):347-8. PMID: 26904794.
Abrol N, Panda A, Kekre NS. Painful varicoceles: Role of varicocelectomy. Indian J Urol. 2014 Oct;30(4):369-73. doi: 10.4103/0970-1591.128497. PMID: 25378815; PMCID: PMC4220373.
Doubleday KL, Kulig K, Landel R. Treatment of testicular pain using conservative management of the thoracolumbar spine: a case report. Arch Phys Med Rehabil. 2003 Dec;84(12):1903-5. doi: 10.1016/s0003-9993(03)00283-1. PMID: 14669201.

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