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Published on: 3/5/2025

What Is Neovascular Age-Related Macular Degeneration (AMD) ?

Neovascular AMD, also called wet AMD, is a type of eye disease that happens when new, abnormal blood vessels grow under the part of your eye that helps you see fine details.

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Explanation

Neovascular age-related macular degeneration is a severe form of AMD that mostly affects older people. In this condition, small blood vessels grow under the macula—the central part of the retina that helps you see clearly. These blood vessels are abnormal, and they can leak fluid or blood into the eye. When they do this, the macula can swell and not work correctly, leading to a faster loss of central vision. This loss of central vision can make everyday tasks such as reading, driving, or recognizing faces difficult. Doctors often call this "wet" AMD because of the leakage, which contrasts with the slower, "dry" form of AMD seen in many patients. Early detection is important so treatment can help slow down the vision loss. Treatments may involve medicines that block the growth of these unwanted blood vessels and reduce the leaks. Regular eye checks are critical, especially for older adults, to catch any signs early and start treatment as soon as possible.

(References)

  • Pugazhendhi A, Hubbell M, Jairam P, Ambati B. Neovascular Macular Degeneration: A Review of Etiology, Risk Factors, and Recent Advances in Research and Therapy. Int J Mol Sci. 2021 Jan 25;22(3):1170. doi: 10.3390/ijms22031170. PMID: 33504013; PMCID: PMC7866170.

  • Ricci F, Bandello F, Navarra P, Staurenghi G, Stumpp M, Zarbin M. Neovascular Age-Related Macular Degeneration: Therapeutic Management and New-Upcoming Approaches. Int J Mol Sci. 2020 Nov 3;21(21):8242. doi: 10.3390/ijms21218242. PMID: 33153227; PMCID: PMC7662479.

  • Shao J, Choudhary MM, Schachat AP. Neovascular Age-Related Macular Degeneration. Dev Ophthalmol. 2016;55:125-36. doi: 10.1159/000438969. Epub 2015 Oct 26. PMID: 26501146.

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