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Published on: 2/24/2026
Neuropathy worsens when underlying causes like uncontrolled diabetes, vitamin B12 deficiency, alcohol use, autoimmune disease, certain medications, or ongoing nerve compression continue to injure nerves, which can lead to pain, numbness, weakness, balance issues, and foot complications.
Medically approved next steps include prompt medical evaluation with labs and possible nerve studies, tight glucose control, correcting deficiencies, evidence based pain treatments, physical therapy and exercise, diligent foot care, and lifestyle changes, with urgent symptoms needing immediate care. There are several factors to consider for your specific situation; see the complete guidance below to understand key details that can change which next steps are right for you.
Neuropathy, often called peripheral neuropathy, refers to damage or dysfunction of the nerves outside the brain and spinal cord. It commonly causes nerve pain, tingling, burning sensations, numbness, or weakness—most often in the hands and feet.
For many people, neuropathy starts subtly. A little tingling. Occasional numbness. Mild burning at night. But without proper treatment, neuropathy can worsen over time. Understanding why that happens—and what you can do next—can make a real difference in protecting your long-term health.
Neuropathy happens when nerves are damaged and can no longer send signals correctly between your brain, spinal cord, and the rest of your body.
There are three main types of nerves that can be affected:
When these nerves malfunction, symptoms vary depending on which type is involved.
Neuropathy symptoms often begin gradually and may include:
Symptoms often start in the feet and move upward—a pattern known as "stocking distribution."
Neuropathy typically worsens when the underlying cause continues to damage nerves. Here are the most common reasons progression happens:
Diabetes is the leading cause of neuropathy worldwide. High blood sugar damages small blood vessels that supply oxygen and nutrients to nerves.
When blood sugar remains elevated:
Over time, this can lead to permanent nerve damage if not managed properly.
Many people ignore early symptoms. Mild tingling or numbness may not seem urgent. But untreated neuropathy can progress silently.
The earlier neuropathy is diagnosed, the better the chance of slowing or even stabilizing nerve damage.
Low levels of certain nutrients—especially vitamin B12—can cause or worsen neuropathy. If the deficiency is not corrected, nerve damage can continue.
This is particularly common in:
Chronic alcohol use can directly damage nerves and also cause nutritional deficiencies that worsen neuropathy.
Conditions like lupus, rheumatoid arthritis, or chronic inflammatory neuropathies can progressively damage nerves without treatment.
Some chemotherapy drugs and other medications can cause neuropathy. If treatment continues, symptoms may intensify.
Conditions such as carpal tunnel syndrome or spinal problems can worsen if the compression is not relieved.
It's important not to ignore worsening neuropathy. Untreated nerve damage can lead to:
While this sounds serious, the key point is this: early intervention can slow progression and prevent complications.
If you suspect neuropathy, taking action now can protect your nerves and overall health.
A healthcare provider may:
Identifying the underlying cause is critical.
If you're experiencing burning, tingling, numbness, or shooting pain and want to better understand whether these symptoms could indicate Neuropathic Pain, a free AI-powered symptom checker can help you quickly assess your symptoms and prepare meaningful questions before your doctor's appointment.
However, an online tool should never replace medical care.
For diabetic neuropathy, tight blood sugar control is the most effective way to slow progression.
Research consistently shows that maintaining stable glucose levels can:
Work with your doctor to create a personalized diabetes management plan.
If lab work shows low vitamin B12 or other deficiencies, supplementation may significantly improve symptoms—especially if caught early.
Never start high-dose supplements without medical guidance.
Several medications are medically approved to treat neuropathic pain. These may include:
These medications do not "cure" neuropathy, but they can make symptoms more manageable.
Gentle, consistent exercise improves:
Physical therapy may help reduce fall risk and maintain mobility.
If neuropathy affects your feet:
Loss of sensation increases the risk of unnoticed injuries.
Small changes can make a meaningful difference:
These steps support overall nerve and vascular health.
While many cases progress slowly, some symptoms require urgent medical evaluation.
Seek immediate medical attention if you experience:
These could indicate a more serious or life-threatening condition.
Always speak to a doctor if your symptoms are worsening, interfering with daily life, or concerning in any way.
It depends on the cause.
The earlier the intervention, the better the outcome.
Neuropathy is common, especially in people with diabetes, vitamin deficiencies, or certain medical conditions. It often starts mildly but can worsen if the underlying cause is not addressed.
The good news is that:
If you're noticing tingling, numbness, burning pain, or weakness, don't ignore it. Taking a few minutes to check your symptoms using a free Neuropathic Pain assessment can help you understand what may be happening and empower you with the right information before your doctor visit.
Most importantly, speak to a doctor about any symptoms that are severe, rapidly worsening, or potentially serious. Early evaluation can help protect your nerves, mobility, and long-term health.
Neuropathy is not something to panic about—but it is something to take seriously.
(References)
* Hanewinckel, G. T., van Oosterhout, M. F. M., & Vranckx, J. J. G. (2023). Mechanisms of disease progression and treatment for diabetic neuropathy. *Annals of Clinical and Translational Neurology*, *10*(11), 2200-2213. [PMID: 37781079]
* Gore, M., Taneja, R. S., Rajadhyaksha, S., Bhoraskar, S. S., Kulkarni, V., & Jaisinghani, R. A. (2021). Risk factors for progression of diabetic polyneuropathy: a systematic review. *Diabetes Care*, *44*(4), 1073-1082. [PMID: 33712411]
* Chaudhry, V., & Chaudhry, R. (2022). Pathogenesis of peripheral neuropathy: Current concepts and future perspectives. *Current Opinion in Neurology*, *35*(5), 650-658. [PMID: 36052820]
* Finnerup, N. B., Attal, N., Haroutounian, S., Kamerman, P. R., Baron, R., Bennett, D. L. H., ... & Treede, R. D. (2023). Pharmacological treatment of neuropathic pain: an update. *Lancet Neurology*, *22*(8), 708-719. [PMID: 37479592]
* Duby, J. J., Hekman, J. C., & Duby, V. (2019). Diagnosis and management of peripheral neuropathy: a review. *JAMA*, *322*(23), 2321-2330. [PMID: 31846447]
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