Published on: 8/19/2025
What is NES/T and how does it work as a male contraceptive?
NES/T is a male contraceptive gel that combines two hormones, nestorone and testosterone, to reduce sperm production and prevent pregnancy.
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Explanation
NES/T is a male contraceptive that combines testosterone and a hormone called nestorone into a gel. This gel is applied to the skin.
How It Works:
- Nestorone: This hormone stops the body from making its own testosterone, which is needed for sperm production.
- Testosterone: This hormone in the gel helps keep normal male characteristics like muscle and hair growth.
When used together, these hormones lower sperm production to levels that make pregnancy very unlikely. The gel is applied daily to the skin, usually on the shoulders or upper arms. Studies have shown that this method is effective in reducing sperm count, which is essential for contraception.
Using NES/T is a non-invasive and reversible method, meaning that when you stop using it, sperm production can return to normal levels. This makes it a promising option for men seeking temporary contraception.
(References)
- Anawalt BD, Roth MY, Ceponis J, Surampudi V, Amory JK, Swerdloff RS, et al. (2019). Combined nestorone-testosterone gel suppresses serum .... Andrology, 30969032.
- Ilani N, Roth MY, Amory JK, Swerdloff RS, Dart C, Page ST, et al. (2012). A new combination of testosterone and nestorone .... The Journal of clinical endocrinology and metabolism, 22791756.
- Mahabadi V, Amory JK, Swerdloff RS, Bremner WJ, Page ST, Sitruk-Ware R, et al. (2009). Combined transdermal testosterone gel and the progestin .... The Journal of clinical endocrinology and metabolism, 19366848.
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