What is YCT-529 and how does it work as a male birth control pill?

Reviewed by Yoshinori Abe, MD

Internal Medicine

YCT-529 is a male birth control pill that works by targeting the retinoid signaling pathway, which is important for sperm production.

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Explanation

YCT-529 is a new kind of male birth control pill that focuses on the retinoid signaling pathway. This pathway is crucial because it helps in the creation of sperm. By targeting this pathway, YCT-529 aims to stop sperm from being made, which can prevent pregnancy.

How It Works

Retinoid Signaling Pathway: This is a system in the body that uses vitamin A to help make sperm.
Targeting the Pathway: YCT-529 blocks this pathway, so sperm cells don't develop properly.

Benefits

Non-Hormonal: Unlike some other methods, YCT-529 doesn't change hormone levels in the body.
Reversible: The effects are meant to be temporary, so sperm production can return to normal after stopping the pill.

This approach is still being studied, but it offers a promising new way for men to take control of birth control.

(References)

Mannowetz N, Chung SSW, Maitra S, Noman MAA, Wong HL, Cheryala N, et al. (2025). Targeting the retinoid signaling pathway with YCT-529 for .... Communications medicine, 40082579.

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