Doctors Note Logo

Published on: 11/6/2025

What's the difference between NSAIDs and steroids?

NSAIDs and steroids are both used to reduce inflammation and pain, but they work differently in the body and have different side effects. See below to understand more.

answer background

Explanation

NSAIDs, like ibuprofen, are medications that help reduce pain and inflammation by blocking certain chemicals in the body. They are commonly used for headaches, arthritis, and other minor aches. However, they can cause stomach upset and, with long-term use, may lead to stomach ulcers or kidney problems.

Steroids, such as prednisone, are powerful medicines that also reduce inflammation but in a different way. They are often used for more serious conditions like asthma or autoimmune diseases. While effective, steroids can have side effects like weight gain, high blood pressure, and weakened bones if used for a long time.

Key Differences:

  1. Mechanism of Action: NSAIDs block specific enzymes to reduce inflammation, while steroids alter the immune response.
  2. Uses: NSAIDs are often used for everyday pain, whereas steroids are reserved for more serious inflammatory conditions.
  3. Side Effects: NSAIDs can affect the stomach and kidneys, while steroids can impact weight, blood pressure, and bone strength.

Understanding these differences can help in choosing the right medication for different health needs.

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Was this page helpful?

Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.