Chronic Inflammatory Demyelinating Polyneuropathy Quiz

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Neurology

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Learn more about Chronic inflammatory demyelinating polyneuropathy

Content updated on Sep 20, 2022

What is chronic inflammatory demyelinating polyneuropathy?

Chronic inflammatory demyelinating polyneuropathy (CIDP) or chronic relapsing polyneuropathy occurs when immune system attacks the myelin sheaths (protective fatty covering) around the nerves. The exact triggers are unclear but could be systemic conditions like liver disease, diabetes, infections, cancer, immune system disorders, etc.

Symptoms of chronic inflammatory demyelinating polyneuropathy

  • Decreased sensation over skin

  • Numbness anywhere from the knees to the ankles

  • Numbness or abnormal sensation

  • Numbness in the region from shoulder to elbow

  • Unable to move both arms

  • Hands and legs became clumsy - I cannot do fine work with them

  • Weakness in arms or legs

  • Tingling or prickling sensation of the skin

Questions your doctor may ask to check for chronic inflammatory demyelinating polyneuropathy

Your doctor may ask these questions to diagnose chronic inflammatory demyelinating polyneuropathy

  • Do you feel the sensation on your skin has changed?

  • Do you have numbness from your knees down (such as ankles)?

  • Do you feel any numbness or change in sensation?

  • Do you have numbness from the shoulder to elbow?

  • Are you unable to move both arms?

Treatment for chronic inflammatory demyelinating polyneuropathy

Treatment for CIDP includes physiotherapy, steroids, immune-suppressing drugs and intravenous immunoglobulin. Physiotherapy aims to improve function and prevent shrinkage of muscles and tendons.

View the symptoms of Chronic inflammatory demyelinating polyneuropathy

Diseases related to Chronic inflammatory demyelinating polyneuropathy

References

  • Kuwabara S, Misawa S. Chronic Inflammatory Demyelinating Polyneuropathy. Adv Exp Med Biol. 2019;1190:333-343. doi: 10.1007/978-981-32-9636-7_21. PMID: 31760654.

    https://link.springer.com/chapter/10.1007/978-981-32-9636-7_21

  • Lehmann HC, Burke D, Kuwabara S. Chronic inflammatory demyelinating polyneuropathy: update on diagnosis, immunopathogenesis and treatment. J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):981-987. doi: 10.1136/jnnp-2019-320314. Epub 2019 Apr 16. PMID: 30992333.

    https://jnnp.bmj.com/content/90/9/981

  • Rodríguez Y, Vatti N, Ramírez-Santana C, Chang C, Mancera-Páez O, Gershwin ME, Anaya JM. Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease. J Autoimmun. 2019 Aug;102:8-37. doi: 10.1016/j.jaut.2019.04.021. Epub 2019 May 6. PMID: 31072742.

    https://www.sciencedirect.com/science/article/abs/pii/S0896841119300435?via%3Dihub

  • Muley SA, Jacobsen B, Parry G, Usman U, Ortega E, Walk D, Allen J, Pasnoor M, Varon M, Dimachkie MM. Rituximab in refractory chronic inflammatory demyelinating polyneuropathy. Muscle Nerve. 2020 May;61(5):575-579. doi: 10.1002/mus.26804. Epub 2020 Jan 21. PMID: 31922613.

    https://onlinelibrary.wiley.com/doi/10.1002/mus.26804

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Shohei Harase

Shohei Harase, MD

Neurology

Kameda Medical Center, Japan

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Sanshiro Kato, MD

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Kawai Clinic, Japan

Yu Shirai

Yu Shirai, MD

Psychiatry

Yotsuya Yui Clinic, Japan

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Bayshore Health Centre, India

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National Center for Child Health and Development, Japan

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