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Published on: 4/7/2025

What Might Be the Reason for Numbness in My Left Breast?

Numbness in your left breast might happen when nerves in the area are affected by treatments like surgery or chemotherapy, or sometimes by the cancer itself.

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Explanation

When someone has breast cancer or is treated for it, nerves in the breast area can sometimes get hurt. For example, if you have surgery such as a mastectomy, some nerves might be cut or damaged, which can lead to numbness. This change in feeling is common because the nerves that help you sense touch might not work as well after surgery. Also, some medicines used for treating breast cancer, called chemotherapy drugs, can affect nerves elsewhere in the body, causing what we call chemotherapy-induced neuropathy. This means your brain might not receive the usual signals from the breast area. In some cases, the cancer itself might affect the nerves near it, leading to a loss of sensation. It is important to speak with your doctor about any unusual feelings or changes. They can check your health, review your treatments, and help decide if the numbness is related to treatment changes or something else. Understanding the cause can help guide any necessary steps to make you feel better.

(References)

  • Qin X, Cao Y. Prognostic Biomarker NUMB Is Inhibited by Breast Cancer Cell Exosomes to Promote Breast Cancer Progression. J Immunol Res. 2022 Apr 18;2022:6032076. doi: 10.1155/2022/6032076. PMID: 35478938; PMCID: PMC9038436.

  • Lindau ST, Pinkerton EA, Abramsohn EM, Fuller CM, Grubb D, Mendoza T, Siston AK. Importance of Breast Sensation After Mastectomy: Evidence from Three Sources. Womens Health Rep (New Rochelle). 2023 Dec 4;4(1):594-602. doi: 10.1089/whr.2023.0106. PMID: 38099078; PMCID: PMC10719638.

  • Zhi WI, Chen P, Kwon A, Chen C, Harte SE, Piulson L, Li S, Patil S, Mao JJ, Bao T. Chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer survivors: a comparison of patient-reported outcomes and quantitative sensory testing. Breast Cancer Res Treat. 2019 Dec;178(3):587-595. doi: 10.1007/s10549-019-05416-4. Epub 2019 Aug 27. PMID: 31456070; PMCID: PMC6819268.

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