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Published on: 9/15/2026

Can a swollen lymph node under my right armpit be caused by a vaccine or infection?

Yes, a swollen lymph node under your right armpit is commonly caused by an infection or by a recent vaccine given in that arm, since lymph nodes enlarge as your immune system responds nearby. Vaccine-related swelling (including flu, COVID-19, or shingles vaccines) usually appears within days and fades over a few weeks, while infections such as a skin wound, cat scratch, strep, mono, or a breast infection can also trigger tender swelling. Less often, persistent, hard, painless, or growing nodes can signal something more serious, so timing, texture, and accompanying symptoms matter. There are several important factors to consider, including when to seek care, which are explained below.

Because armpit swelling has many overlapping causes, the fastest way to sort out what is likely happening is a free, instant online symptom check that reviews your symptoms and timing, then guides you on whether to monitor at home or see a clinician now.

Last reviewed for medical accuracy: 09/14/2026

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Explanation

Can a swollen lymph node under my right armpit be caused by a vaccine or infection?
(Optimized for: pain under right armpit female)

A tender, swollen lymph node under your right armpit can feel alarming, especially for a woman noticing pain under right armpit female. In most cases, this enlargement is a sign your body is fighting something – often a routine immune response to a vaccine or a minor infection. Let’s break down why this happens, what to look out for, and when to seek further evaluation.

How lymph nodes work

  • Lymph nodes are small, bean-shaped glands scattered along lymphatic vessels.
  • They filter lymph fluid and trap viruses, bacteria and abnormal cells.
  • When they detect a threat, they “ramp up” white blood cell production, swelling in the process.

Under the arm (the axilla) you have several lymph nodes that drain the skin, breast tissue and arm. Swelling there can cause discomfort or pain under right armpit female patients often describe as a dull ache or pressure.


Common causes of swollen axillary lymph nodes

  1. Vaccine-related lymphadenopathy

    • Vaccines stimulate your immune system to build protection.
    • It’s normal to see temporary, mild swelling in nearby lymph nodes (usually on the same side as the injection).
    • Reports after COVID-19 or flu shots have shown lymph node enlargement lasting a few days to a couple of weeks.
  2. Local skin or soft-tissue infections

    • An ingrown hair, a small cut or insect bite on the arm or chest wall can introduce bacteria.
    • Staphylococcus or streptococcal infections often cause tender, warm, red nodes.
  3. Systemic viral infections

    • Common viruses (mononucleosis, chickenpox, cytomegalovirus) may trigger generalized lymph node swelling.
    • Nodes may be tender, mobile and accompanied by fever, fatigue or sore throat.
  4. Bacterial infections beyond the skin

    • Cat‐scratch disease (Bartonella henselae) from a scratch or bite can cause tender axillary nodes.
    • Tuberculosis or atypical mycobacteria rarely affect axillary nodes but can in endemic areas.
  5. Other causes

    • Autoimmune conditions (lupus, rheumatoid arthritis) can cause low‐grade node enlargement.
    • Malignancies (lymphoma, leukemia, breast cancer metastasis) may present as firm or hard, non-tender nodes.

Why vaccines can cause under-arm swelling

When you receive an injection:

  • Antigens in the vaccine activate nearby immune cells.
  • Those cells travel to regional lymph nodes (often the axilla if your shot was in the upper arm).
  • As they multiply and produce antibodies, the node may enlarge and feel sensitive.
  • This reaction is generally mild, peaking within a few days and resolving over 1–3 weeks.

Key points:

  • Onset usually 1–7 days after vaccination.
  • Mild pain or fullness, no overlying skin redness in most cases.
  • No fever or systemic symptoms beyond minor fatigue or low-grade fever.

What an infection-related swollen node looks like

  • Tenderness: Often painful to touch.
  • Redness and warmth: Especially with bacterial causes.
  • Accompanying symptoms: Fever, chills, localized rash or pus at an entry site.
  • Mobility: Nodes in infection are usually soft to rubbery and can be moved slightly under the skin.

When to worry: red flags

While most lumps are benign, see a doctor promptly if you notice any of the following in your right armpit:

  • Hard, immovable nodes larger than 2 cm.
  • Persistence beyond 6 weeks without signs of improvement.
  • Rapid growth over days.
  • Night sweats, unexplained weight loss, or persistent high fevers.
  • Overlying skin changes: persistent redness, non-healing wounds.
  • Pain that wakes you at night or limits daily activities.

Evaluation and diagnosis

Your healthcare provider may recommend:

  • Physical exam: Assess size, consistency and tenderness.
  • Blood tests: Look for infection markers (CBC, inflammatory markers).
  • Imaging: Ultrasound of the axilla to characterize the node.
  • Biopsy: Fine-needle aspiration or excisional biopsy if malignancy is suspected.

Self-care tips

  • Warm compresses: Apply for 10–15 minutes, 2–3 times daily.
  • Over-the-counter pain relief: NSAIDs like ibuprofen can ease pain and inflammation.
  • Rest and hydration: Support your immune system.
  • Gentle arm movement: Prevent stiffness but avoid strenuous lifting until pain subsides.

Beyond lymph nodes: other causes of armpit pain in women

Pain under right armpit female patients might also relate to:

  • Muscle strain: From lifting, sports or posture issues.
  • Nerve irritation: Thoracic outlet syndrome or pinched nerves in the neck.
  • Breast changes: Fibrocystic changes or infections (mastitis).
  • Skin conditions: Hidradenitis suppurativa or cysts.

If swelling isn’t evident but pain persists, your doctor may explore these other avenues.


Next steps if you’re unsure

If you’re feeling uncertain about your symptoms, consider a free, online symptom check, using the doctor approved Ubie Symptom Checker. This quick tool can help you sort through common causes and suggest when to seek medical attention.


When to speak to a doctor

Always contact a healthcare professional if you experience:

  • Severe or rapidly worsening pain under right armpit female.
  • Any of the red-flag signs listed above.
  • Concern that something feels “seriously wrong” or life threatening.

Your doctor can provide a thorough evaluation and, if needed, specialist referral.


Bottom line:
Swollen lymph nodes under your right armpit are most often due to routine immune responses—either from a recent vaccine in that arm or an infection nearby. In the vast majority of cases, they resolve on their own over days to weeks. However, persistent, hard or rapidly growing nodes, especially when paired with systemic symptoms, warrant prompt medical attention.

If you ever feel uncertain, don’t hesitate to use a free, online symptom check, using the doctor approved Ubie Symptom Checker or discuss your concerns directly with a healthcare provider. Your vigilance and timely care ensure the best outcome.

(References)

  • * Ali S, Almoudaris M. BCG lymphadenitis. Arch Dis Child. 2004 Sep;89(9):812. doi: 10.1136/adc.2003.042838. PMID: 15321853; PMCID: PMC1763200.

  • * Cheung L, Henderson AH, Banfield G, Carswell A. Bilateral isolated submandibular gland mumps. BMJ Case Rep. 2017 Jun 5;2017. doi: 10.1136/bcr-2017-220103. Epub 2017 Jun 5. PMID: 28583925; PMCID: PMC5534970.

  • * Bedi N, Rahimi MNC, Menzies S, Kalsi J. Atypical testicular pain. BMJ Case Rep. 2019 Feb 19;12(2). doi: 10.1136/bcr-2018-226697. Epub 2019 Feb 19. PMID: 30787023; PMCID: PMC6388880.

  • * Washington T, Bryan R, Clemow C. Adenopathy Following COVID-19 Vaccination. Radiology. 2021 Jun;299(3):E280-E281. doi: 10.1148/radiol.2021210236. Epub 2021 Feb 24. PMID: 33625299; PMCID: PMC7909073.

  • * Shin M, Hyun CY, Choi YH, Choi JY, Lee KH, Cho YS. COVID-19 Vaccination-Associated Lymphadenopathy on FDG PET/CT: Distinctive Features in Adenovirus-Vectored Vaccine. Clin Nucl Med. 2021 Oct 1;46(10):814-819. doi: 10.1097/RLU.0000000000003800. PMID: 34115709; PMCID: PMC8411598.

  • * Duke H, Posch L, Green L. Axillary adenopathy following COVID-19 vaccination: A single institution case series. Clin Imaging. 2021 Dec;80:111-116. doi: 10.1016/j.clinimag.2021.05.023. Epub 2021 Jun 1. PMID: 34303188; PMCID: PMC8166813.

  • * Surasi DSS, Lin L, Ravizzini G, Wong F. Supraclavicular and Axillary Lymphadenopathy Induced by COVID-19 Vaccination on 18F-Fluorthanatrace, 68Ga-DOTATATE, and 18F-Fluciclovine PET/CT. Clin Nucl Med. 2022 Feb 1;47(2):195-196. doi: 10.1097/RLU.0000000000003891. PMID: 34507331.

  • * Ganga K, Solyar AY, Ganga R. Massive Cervical Lymphadenopathy Post-COVID-19 Vaccination. Ear Nose Throat J. 2024 Apr;103(4):255-257. doi: 10.1177/01455613211048984. Epub 2021 Oct 2. PMID: 34601889.

  • * Raj S, Ogola G, Han J. COVID-19 Vaccine-Associated Subclinical Axillary Lymphadenopathy on Screening Mammogram. Acad Radiol. 2022 Apr;29(4):501-507. doi: 10.1016/j.acra.2021.11.010. Epub 2021 Nov 17. PMID: 34906409; PMCID: PMC8595349.

  • * Heath CR, Usatine RP. Tinea capitis. J Fam Pract. 2022 Oct;71(8):370-371. doi: 10.12788/jfp.0493. PMID: 36508560.

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