Published on: 3/17/2025
A lump on the perineum in females can be caused by benign conditions such as an epidermoid cyst, endometriosis, or a soft-tissue tumor like a myoma, and doctors usually diagnose these with a physical exam, imaging tests, and sometimes a tissue biopsy.
A lump in the perineum—the area between the vagina and the anus—can be due to several different causes. One common cause is an epidermoid cyst, which is a small, benign pocket filled with skin cells. This type of cyst is not usually dangerous but can be uncomfortable if it grows or becomes irritated. Another possibility is endometriosis in the perineum. In this condition, cells similar to those that line the uterus grow in this area, causing pain, especially during periods. In rare cases, the lump might be a soft-tissue tumor, such as a myoma (a type of benign growth). To find out what is causing the lump, a healthcare provider will start with a careful physical exam. They may also use imaging tests like an ultrasound or an MRI to see the lump more clearly. In some situations, a small sample of tissue (a biopsy) is taken to study it under a microscope. These steps help the doctor decide on the best treatment plan, which might include monitoring the lump or removing it if needed.
(References)
Saeed U, Mazhar N. Epidermoid cyst of perineum: a rare case in a young female. BJR Case Rep. 2016 Oct 7;3(1):20150352. doi: 10.1259/bjrcr.20150352. PMID: 30363255; PMCID: PMC6159278.
Nasu K, Okamoto M, Nishida M, Narahara H. Endometriosis of the perineum. J Obstet Gynaecol Res. 2013 May;39(5):1095-7. doi: 10.1111/jog.12003. Epub 2013 Mar 17. PMID: 23496239.
Ben Haj Hassine MA, Arfaoui R, Siala H, Trabelsi H, Rachdi R. Soft-tissue tumor of the perineum: an exceptional case of bilateral perineal myoma. Clin Case Rep. 2015 Feb;3(2):99-101. doi: 10.1002/ccr3.164. Epub 2014 Nov 17. PMID: 25767706; PMCID: PMC4352362.
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