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Published on: 2/23/2026
Burning, tingling, or numbness in the hands or feet is often peripheral neuropathy from damaged peripheral nerves. Diabetes is the most common cause, but vitamin B12 deficiency, alcohol use, autoimmune disease, infections, certain medications, thyroid, kidney or liver disease, and toxins can also be responsible, and treating the cause early can reverse or slow damage. There are several factors to consider, including urgent red flags like sudden weakness, breathing trouble, or loss of bladder or bowel control that need immediate care; for ongoing symptoms, next steps include seeing a clinician for blood sugar, B12, thyroid, kidney and liver tests, medication review, and possible nerve studies, with more details that could change your plan outlined below.
If you feel burning, tingling, numbness, or electric-shock sensations in your hands or feet, you may be experiencing peripheral neuropathy. These symptoms can start gradually and feel mild at first. Over time, they can become more noticeable and interfere with daily life.
Peripheral neuropathy is common, especially in adults over 40 and in people with diabetes. While the word "neuropathy" may sound alarming, understanding what's happening in your body — and what to do next — can make a real difference.
Let's break it down clearly and practically.
Peripheral neuropathy happens when the peripheral nerves — the nerves outside your brain and spinal cord — become damaged.
These nerves control:
When they are damaged, signals between your brain and body get disrupted. That's why symptoms can feel confusing or unpredictable.
Symptoms often begin in the feet and hands. This is called a "stocking and glove" pattern.
You may notice:
In more advanced cases:
Symptoms may be mild at first. Some people ignore them for months or even years. But early action matters.
Peripheral neuropathy is not a disease itself. It's a result of nerve damage from another condition.
The leading cause of peripheral neuropathy is diabetes.
High blood sugar over time damages small blood vessels that feed your nerves. Without proper blood flow and nutrients, nerves begin to malfunction.
This condition is called diabetic neuropathy.
If you have diabetes — or even prediabetes — nerve symptoms should never be ignored. Taking a free AI-powered Diabetic Neuropathy symptom checker can help you identify warning signs and understand whether your symptoms match this condition before your next doctor visit.
Low levels of certain vitamins, especially:
can damage nerves. B12 deficiency is particularly common and treatable.
Long-term heavy alcohol use can:
Diseases like:
can cause the immune system to attack nerves.
Certain infections may trigger peripheral neuropathy, including:
Some chemotherapy drugs and certain medications can damage nerves as a side effect.
In some cases, no clear cause is found. This is called idiopathic peripheral neuropathy.
While peripheral neuropathy often develops slowly, there are symptoms that require prompt medical attention.
Seek urgent care if you experience:
These could signal a more serious condition.
For ongoing symptoms like numbness or burning, schedule a doctor's visit soon — especially if you have diabetes or other risk factors.
Diagnosis usually involves several steps.
Your doctor will ask about:
They may check:
Common tests look for:
In some cases, you may need:
These tests measure how well your nerves transmit signals.
This depends on the cause.
Some forms of peripheral neuropathy can improve if the underlying issue is treated quickly.
For example:
The earlier the damage is addressed, the better the chance of improvement.
In long-standing cases, nerves may not fully recover. However:
Treatment focuses on two goals:
Doctors may recommend:
Lifestyle changes can also help:
For people with diabetes, daily foot care is essential. Numbness increases the risk of unnoticed injuries that can lead to infection.
Peripheral neuropathy often starts quietly.
A little numbness. A little tingling. A little burning at night.
Ignoring it allows nerve damage to progress.
Addressing it early can:
Especially in diabetic neuropathy, early intervention can significantly slow progression.
If you're experiencing burning or numbness:
If you're concerned about diabetes-related nerve damage, use this free Diabetic Neuropathy assessment tool to evaluate your symptoms and gather helpful information to discuss with your doctor.
Peripheral neuropathy is common — but it is not something to ignore.
Burning, tingling, and numbness are signals from your body that something needs attention. In many cases, identifying and treating the cause early can prevent further nerve damage.
Do not panic. But do take action.
If your symptoms are severe, worsening, or interfering with daily life, speak to a doctor promptly. If you experience sudden weakness, breathing difficulty, or loss of bladder control, seek emergency care immediately.
Your nerves are vital to everything you do — from walking to feeling to staying balanced. Taking symptoms seriously today can protect your health tomorrow.
If you're unsure about your risk, start by learning more, checking your symptoms, and having an open conversation with your healthcare provider.
(References)
* Coyle MJ, Sforza J, Coyle MM, Alper C, Tavee JO. Peripheral neuropathy: What causes it, what is the best treatment? Cleve Clin J Med. 2022 Feb 1;89(2):93-102. PMID: 35105658.
* Gemignani F, Cotti Piccinelli S, De Amicis D, Brindani M, Ferrari D. Small Fiber Neuropathy: Clinical Spectrum and Pathophysiological Mechanisms. Brain Sci. 2022 Mar 23;12(4):427. PMID: 35448057.
* Chen Y, Yu R, Yang Y, Zhang F, Yu H, Gao J, Zheng Y, Li H, Chen Z. Molecular Mechanisms of Neuropathic Pain: Recent Advances. Cells. 2023 Feb 24;12(5):713. PMID: 36899757.
* Jia X, Han J, Wang Z, Ding W, Zhou Z, Xu T, Wei W. Peripheral nerve regeneration: a comprehensive review. Burns Trauma. 2021 Mar 1;9:tkab008. PMID: 33680872.
* Verkhlyutov V, Othman F, Moinuddin A, Almatrafi A, Ghouse I, Hajjaj M, Shahrabani K, Fathy H. Autonomic Neuropathy: A Narrative Review. J Diabetes Res. 2023 Mar 2;2023:6727284. PMID: 36909876.
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