How does pitolisant promote wakefulness compared to stimulants?

Pitolisant and stimulants both help people stay awake, but they do it in different ways. Pitolisant works by increasing the activity of a brain chemical called histamine. Histamine is important for keeping us alert and awake during the day.

Stimulants, on the other hand, usually work by increasing the levels of different chemicals in the brain, like dopamine and norepinephrine. These chemicals help with focus and energy.

Key Differences:

1. Mechanism of Action:

   • Pitolisant increases histamine, which is directly involved in wakefulness.
   • Stimulants increase dopamine and norepinephrine, which are more related to focus and energy.

2. Side Effects:

   • Pitolisant might have fewer side effects related to jitteriness and heart rate compared to stimulants.

In summary, pitolisant offers an alternative for promoting wakefulness, especially for people who might not tolerate stimulants well.