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Published on: 11/13/2025
Stimulants and wake-promoting agents both help people with narcolepsy stay awake, but they work differently and have different side effects.
Stimulants, such as amphetamines, are medications that increase brain activity to help people with narcolepsy stay awake during the day. They work by boosting certain chemicals in the brain that help with alertness and focus. However, stimulants can have side effects like increased heart rate and a higher potential for misuse.
Wake-promoting agents, like modafinil, also help people stay awake, but they work differently from stimulants. Modafinil doesn't increase brain activity in the same way as stimulants, which may result in fewer side effects and a lower risk of misuse. According to the studies, modafinil is effective for keeping people awake without the same level of side effects associated with traditional stimulants.
In summary, while both types of medications help manage daytime sleepiness in narcolepsy, they differ in how they work and their potential side effects. It's important for patients to discuss with their doctors which treatment is best for them.
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