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Published on: 11/7/2025
Can I stop PPI suddenly?
It's not recommended to stop proton pump inhibitors (PPIs) suddenly. Gradually reducing the dose may help prevent symptoms from coming back. See below to understand more.
Questions about stopping your PPI use?
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Proton pump inhibitors (PPIs) are medicines that reduce stomach acid. If you stop taking them all of a sudden, your stomach might make a lot of acid again, which can cause symptoms like heartburn.
Why Not Stop Suddenly?
- Stopping PPIs suddenly can cause a rebound effect, where your stomach produces more acid than before.
- This can make symptoms return or even get worse.
What Can You Do?
- Gradually reducing the dose, a process called 'tapering,' can help manage symptoms.
- Talk to your doctor about the best way to decrease your dosage safely.
Remember:
- Always discuss with a healthcare provider before making changes to your medication.
- They can help create a plan that works for you and keeps you comfortable.
(References)
- Kurlander JE, Kennedy JK, Rubenstein JH, Richardson CR, Krein SL, De Vries R, & Saini SD. (2019). Patients' Perceptions of Proton Pump Inhibitor Risks and .... The American journal of gastroenterology, 30694867.
- Wehmeyer MH, Horvatits T, Buchholz A, Krause L, Walter S, Zapf A, et al. (2022). Stop of proton-pump inhibitor treatment in patients with .... Trials, 35414106.
- Coyle C, Symonds R, Allan J, Dawson S, Russell S, Smith A, et al. (2019). Sustained proton pump inhibitor deprescribing among .... BJGP open, 31581112.
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