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Published on: 11/7/2025
Does PPI use increase risk of infection?
Using proton pump inhibitors (PPIs) may increase the risk of certain infections, especially in the stomach and intestines. See below to understand more.
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Proton pump inhibitors (PPIs) are medications that reduce the amount of acid in the stomach. According to the provided references, using PPIs might increase the risk of infections.
How PPIs Affect Infection Risk:
- Stomach Environment: PPIs lower stomach acid, which normally helps kill harmful bacteria.
- Increased Susceptibility: With less acid, certain bacteria can survive and grow, potentially leading to infections.
Types of Infections:
- Gastrointestinal Infections: PPIs are linked to a higher risk of gut infections like C. difficile, which can cause diarrhea.
- Respiratory Infections: There might also be a small increase in the risk of lung infections.
While PPIs can be helpful for treating stomach issues, it's important to use them carefully and only when needed to minimize these risks. Always discuss with a healthcare provider before starting or stopping any medication.
(References)
- Bavishi C, & Dupont HL. (2011). the use of proton pump inhibitors and increased susceptibility .... Alimentary pharmacology & therapeutics, 21999643.
- Moayyedi P, & Leontiadis GI. (2012). The Risks of PPI Therapy. Nature reviews. Gastroenterology & hepatology, 22330810.
- Jaynes M, & Kumar AB. (2019). The risks of long-term use of proton pump inhibitors. Therapeutic advances in drug safety, 31019676.
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