Do PPIs affect calcium absorption?

Proton pump inhibitors, or PPIs, are medicines that reduce stomach acid. Some studies suggest that PPIs might lower calcium absorption, which is important for strong bones. However, the research is not clear-cut.

• Reference 1 suggests that PPIs can decrease calcium absorption. This might be because less stomach acid makes it harder for the body to absorb calcium.
• Reference 2 found that blocking stomach acid did not change how calcium is absorbed in the intestines.
• Reference 3 talks about long-term PPI use and its possible effects on calcium metabolism, but it does not give a definite answer.

In summary, while there is some concern about PPIs affecting calcium absorption, the evidence is not consistent. If you are using PPIs and are worried about calcium, it might be helpful to discuss this with a healthcare provider.