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Published on: 4/28/2025

How Is Preterm Premature Rupture of Membranes Managed in a Clinical Setting?

Doctors carefully watch both mom and baby, give medicine like antibiotics and steroids, and monitor for infections and other issues when a mother has preterm premature rupture of membranes (PPROM).

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Explanation

When a mother’s water breaks before 37 weeks of pregnancy, it is called preterm premature rupture of membranes, or PPROM. In a clinical setting, doctors first confirm the rupture with tests and then decide on the best course of action. They usually keep the mother in the hospital so they can keep a close eye on both her and the baby. One important step is giving antibiotics to help prevent infections, since the protective barrier of the amniotic sac is now broken. Doctors may also give corticosteroids, which are medications that help the baby’s lungs grow and get ready for life outside the womb. In some cases, they might also give magnesium sulfate to protect the baby’s brain, especially if early delivery is likely. The care team monitors the mother’s temperature, heart rate, and other signs to check for any infections, and they watch the baby closely with ultrasound and heart rate monitoring. If signs of infection appear or if the baby shows any distress, the doctors may decide it is best to deliver the baby. This careful balance aims to give the baby the best chance to grow and to keep the mother healthy.

(References)

  • Waters TP, Mercer BM. The management of preterm premature rupture of the membranes near the limit of fetal viability. Am J Obstet Gynecol. 2009 Sep;201(3):230-40. doi: 10.1016/j.ajog.2009.06.049. PMID: 19733274.

  • Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol. 2003 Jan;101(1):178-93. doi: 10.1016/s0029-7844(02)02366-9. PMID: 12517665.

  • Herzlich J, Mangel L, Halperin A, Lubin D, Marom R. Neonatal outcomes in women with preterm premature rupture of membranes at periviable gestational age. Sci Rep. 2022 Jul 14;12(1):11999. doi: 10.1038/s41598-022-16265-5. PMID: 35835823; PMCID: PMC9283543.

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