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Published on: 2/24/2026

Is Reality Slipping Away? The Science of Psychosis & Medical Next Steps

Psychosis is a treatable medical symptom where reality feels distorted by hallucinations, delusions, and disorganized thinking; it can arise from schizophrenia spectrum and mood disorders, substances or withdrawal, sleep loss, certain medications, or medical illnesses like infections and thyroid or autoimmune problems. There are several important factors to consider, including early warning signs like social withdrawal and decline in work or school; see below to understand more.

Next steps include prompt medical evaluation to confirm psychosis, find the cause, and rule out emergencies, especially if there is confusion, fever, severe headache, seizures, or any risk of harm. Evidence based treatments include antipsychotic medicines, therapy, and coordinated specialty care, plus treating any underlying condition; crucial details that could change your decisions about when and where to seek care are outlined below.

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Explanation

Is Reality Slipping Away? The Science of Psychosis & Medical Next Steps

When someone begins to feel disconnected from reality, it can be confusing and frightening. Thoughts may seem jumbled. Sights or sounds may not match what others perceive. Suspicion may grow without clear reason. These experiences can point to psychosis, a serious but treatable medical condition.

Psychosis is not a diagnosis by itself. It is a symptom — one that can occur in several mental health and medical conditions. Understanding what psychosis is, why it happens, and what to do next can make a life-changing difference.


What Is Psychosis?

Psychosis is a condition that affects how the brain processes information. It causes a person to lose touch with reality in some way.

The two most common symptoms are:

  • Hallucinations – Seeing, hearing, or sensing things that are not actually present. Hearing voices is the most common type.
  • Delusions – Strong beliefs that are clearly false or not based in reality, even when evidence shows otherwise.

Other symptoms may include:

  • Disorganized thinking or speech
  • Trouble concentrating
  • Social withdrawal
  • Reduced emotional expression
  • Suspiciousness or paranoia
  • Changes in sleep or behavior

Psychosis can develop gradually or appear suddenly. It can affect teenagers, young adults, and older adults. Early recognition is critical.


What Causes Psychosis?

Psychosis is linked to changes in brain chemistry and brain signaling. Research shows that imbalances in neurotransmitters — especially dopamine — play a key role. Brain imaging studies also suggest differences in how certain areas of the brain communicate.

However, psychosis rarely has just one cause. It often results from a combination of biological, psychological, and environmental factors.

Common causes of psychosis include:

  • Schizophrenia spectrum disorders
  • Bipolar disorder (during manic or depressive episodes)
  • Severe depression with psychotic features
  • Substance use or withdrawal (such as cannabis, stimulants, alcohol)
  • Medical conditions (thyroid disease, infections, autoimmune disorders, brain injury)
  • High fever or delirium
  • Sleep deprivation
  • Certain medications

In young adults, schizophrenia is one of the more well-known causes. In older adults, sudden psychosis may signal a medical problem like infection or metabolic imbalance.

Because psychosis can stem from many conditions, proper medical evaluation is essential.


Early Warning Signs of Psychosis

Psychosis rarely appears without warning. Subtle changes often happen first.

Early signs may include:

  • Withdrawing from friends and family
  • Drop in school or work performance
  • Trouble thinking clearly
  • Increased suspicion or mistrust
  • Emotional flatness
  • Unusual or intense ideas
  • Neglect of personal hygiene

Recognizing these signs early allows for faster treatment — and better outcomes.


Is Psychosis the Same as Schizophrenia?

No. While psychosis is a core symptom of schizophrenia, not everyone who experiences psychosis has schizophrenia.

Schizophrenia is a chronic mental health disorder characterized by:

  • Persistent psychosis
  • Disorganized thinking
  • Negative symptoms (lack of motivation, reduced emotion)
  • Functional decline lasting at least six months

Other conditions can cause temporary psychosis that resolves with treatment.

If you're concerned that symptoms may be pointing toward Schizophrenia, a free AI-powered symptom checker can help you identify patterns and prepare meaningful questions before your medical appointment.

Online tools are not a diagnosis, but they can be a helpful first step.


How Is Psychosis Diagnosed?

There is no single blood test or brain scan that diagnoses psychosis. Instead, doctors use:

  • A detailed medical and psychiatric history
  • A physical exam
  • Mental status evaluation
  • Blood tests to rule out medical causes
  • Sometimes brain imaging

The goal is to determine:

  1. Whether psychosis is present
  2. What is causing it
  3. Whether there is a medical emergency

Sudden psychosis with confusion, fever, severe headache, or neurological symptoms requires immediate medical attention.


Treatment for Psychosis

Psychosis is treatable. Early treatment greatly improves recovery.

1. Antipsychotic Medications

These medications help regulate dopamine and other brain chemicals. They can:

  • Reduce hallucinations
  • Decrease delusions
  • Improve thinking clarity

Medication response varies from person to person. Some side effects may occur, so close monitoring by a doctor is important.

2. Therapy

Psychotherapy can help people:

  • Understand their experiences
  • Develop coping skills
  • Reduce distress related to symptoms
  • Improve daily functioning

Cognitive behavioral therapy (CBT) is often used as part of treatment.

3. Coordinated Specialty Care

For first-episode psychosis, early intervention programs combine:

  • Medication
  • Therapy
  • Family education
  • Employment and school support

Research shows early treatment improves long-term outcomes significantly.

4. Treating Underlying Causes

If psychosis is caused by:

  • A medical condition → Treat the medical issue
  • Substance use → Address withdrawal and recovery
  • Sleep deprivation → Restore healthy sleep

Treatment must match the root cause.


What Happens If Psychosis Is Left Untreated?

It's important not to ignore psychosis. Without treatment, symptoms can:

  • Become more severe
  • Increase risk of harm to self or others
  • Lead to job or school loss
  • Strain relationships
  • Increase risk of hospitalization

However, many people with psychosis improve significantly with proper care. Early intervention reduces long-term complications.

This is serious — but it is also manageable.


When to Seek Immediate Help

Seek urgent medical care if psychosis occurs with:

  • Thoughts of self-harm or suicide
  • Thoughts of harming others
  • Severe confusion
  • High fever
  • Stiff neck or severe headache
  • Seizures
  • Sudden personality change

If anything feels life-threatening or dangerous, call emergency services immediately.


Reducing Risk and Supporting Recovery

While not all cases of psychosis can be prevented, certain steps support brain health:

  • Avoid recreational drug use
  • Get regular sleep
  • Manage stress
  • Treat depression or anxiety early
  • Maintain regular medical checkups

Family support also plays a major role in recovery. Calm, non-judgmental communication helps more than confrontation.


The Bottom Line: Psychosis Is a Medical Condition — Not a Personal Failure

Experiencing psychosis does not mean someone is "crazy" or weak. It reflects changes in how the brain processes reality. Like diabetes or heart disease, it requires medical attention.

The key facts to remember:

  • Psychosis is treatable
  • Early intervention improves outcomes
  • Many causes are manageable
  • Professional evaluation is essential

If you or someone you care about is noticing symptoms of psychosis, do not ignore them. Taking a free online Schizophrenia symptom assessment can help you organize your observations and concerns before meeting with a healthcare provider.

Most importantly, speak to a doctor about any symptoms that could be serious or life-threatening. Prompt medical care can prevent complications and support recovery.

Reality may feel like it's slipping — but with the right help, it can be stabilized again.

(References)

  • * McGuire P, Fusar-Poli P, Pries L, et al. Early psychosis: recent advances and future directions. Transl Psychiatry. 2018 Nov 13;8(1):234. doi: 10.1038/s41398-018-0287-4. PMID: 30425263; PMCID: PMC6233159.

  • * Howes OD, Murray RM, Fusar-Poli P. The Science of Psychosis: Neurobiology, Pathophysiology, and Clinical Implications. JAMA Psychiatry. 2021 May 1;78(5):547-558. doi: 10.1001/jamapsychiatry.2021.0064. PMID: 33764353.

  • * Kambeitz J, Kambeitz-Ilankovic L, Leucht S, Dwyer DB, Fusar-Poli P, Falkai P. The neuroscience of psychosis: implications for diagnosis and treatment. Lancet Psychiatry. 2021 Dec;8(12):1098-1111. doi: 10.1016/S2215-0366(21)00249-1. Epub 2021 Oct 29. PMID: 34720173.

  • * Patel V, Jo PH, Patel A, Jo J, Khan S, Khan Y. Early Psychosis Intervention: A Literature Review. Cureus. 2023 Feb 15;15(2):e35058. doi: 10.7759/cureus.35058. PMID: 36949987; PMCID: PMC10018868.

  • * Stone J, Veltman DJ, Howes OD, Fusar-Poli P, McGuire P. Management of first-episode psychosis: a review. Psychopharmacology (Berl). 2020 Apr;237(4):947-961. doi: 10.1007/s00213-020-05466-9. Epub 2020 Feb 21. PMID: 32080775; PMCID: PMC7070183.

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