Our Services
Medical Information
Helpful Resources
Published on: 4/21/2026
In diabetes, chronically high blood sugar damages the autonomic nerves that regulate heart rate, leading to a resting heart rate of 100 beats per minute or more even when you are inactive. This autonomic neuropathy not only raises your cardiovascular risk but also often presents with blood pressure fluctuations, digestive problems, and other nerve injury symptoms.
There are several factors to consider in diagnosis and management, including specific tests, medications, and lifestyle adjustments, so see below for complete details.
If you have diabetes and notice your heart racing even when you're at rest, you're not alone. A resting heart rate of 100 beats per minute (bpm) or higher in people with diabetes can be a sign of autonomic neuropathy—a condition where the nerves that control involuntary body functions are damaged. In this guide, we'll explain what autonomic neuropathy is, why it causes a fast resting heart rate, how to recognize symptoms, and what steps you can take.
Autonomic neuropathy is a type of nerve damage that affects the autonomic nervous system (ANS). The ANS controls functions you don't consciously think about, such as:
In diabetes, chronically high blood sugar levels can injure small nerve fibers over time. When these fibers in the ANS are damaged, signals between your brain and organs become confused or don't get through.
High glucose levels over time damage the tiny blood vessels (capillaries) that supply nerves with oxygen and nutrients. Key factors include:
Once autonomic fibers to the heart are affected, the regulation of heart rate becomes erratic. Instead of adjusting smoothly for rest or activity, your heart may race even while you're sitting or lying down.
A typical adult resting heart rate is 60–100 bpm. If yours hovers at or above 100 bpm chronically, you may experience:
For someone with diabetes, a resting heart rate of 100 bpm or higher should prompt evaluation for autonomic neuropathy and other cardiac concerns.
Alongside a fast resting heart rate, autonomic neuropathy can cause a variety of signs. You might notice:
Heart-related
Blood pressure fluctuations
Digestive issues
Bladder and sexual function
Temperature regulation
If you're experiencing any combination of these symptoms, it's important to investigate further.
A healthcare provider will begin with a detailed medical history and physical exam, focusing on heart rate and blood pressure changes. Diagnostic tests may include:
Early diagnosis allows you to address symptoms before serious complications develop.
While autonomic neuropathy can't be reversed, you can slow its progression and ease symptoms. Key strategies include:
Optimize blood sugar control
Medications
Lifestyle adjustments
Heart-healthy habits
Regular monitoring
A resting heart rate of 100 bpm can signal more than just autonomic neuropathy. If you experience any of the following, seek medical attention right away:
These could be life-threatening and require immediate evaluation.
If you're concerned about nerve damage contributing to your racing heart and other symptoms, consider using a free Diabetic Neuropathy symptom checker to help identify which specific symptoms to prioritize during your next doctor's visit.
Always speak to a doctor about any symptoms that could be life threatening or serious. Early intervention and consistent management can help you maintain a healthier heart rate and overall well-being.
(References)
* Ziegler D, Papanas N, Vinik AI, Kempler P. Epidemiology, pathophysiology, and management of cardiac autonomic neuropathy in diabetes: a consensus statement by a multi-task force of the European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) Neurodiab and the American Autonomic Society (AAS). Metabolism. 2019 Jun;95:47-63. doi: 10.1016/j.metabol.2019.01.008. Epub 2019 Jan 17. PMID: 30678255.
* Biaggioni I, Perez-Lugones A, Raj SR. Postural Orthostatic Tachycardia Syndrome. N Engl J Med. 2022 Aug 4;387(5):446-455. doi: 10.1056/NEJMcp2117524. PMID: 35940608.
* Ziemssen T, Reichmann H. The cardiovascular manifestations of autonomic neuropathy. Ther Adv Neurol Disord. 2011 May;4(3):141-59. doi: 10.1177/1756285611400262. PMID: 22870341; PMCID: PMC3832812.
* Al-Qishawi A, Sharma S. Cardiovascular Autonomic Dysfunction. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. PMID: 32965935.
* Joung B, Pak HN, Lee MH. Physiological causes of sinus tachycardia: an updated appraisal. J Arrhythm. 2018 Dec;34(6):579-585. doi: 10.1002/joa3.12104. Epub 2018 Sep 28. PMID: 30282662; PMCID: PMC6309874.
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.