Published on: 7/24/2025
Are seniors more prone to muscle loss on GLP-1s?
Seniors taking GLP-1 medications may be more likely to experience muscle loss, especially with drugs like semaglutide.
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Explanation
Some studies suggest that seniors taking GLP-1 medications, such as semaglutide, might be more at risk for losing muscle.
- Muscle Mass Concerns: Research has shown that these medications can lead to changes in body composition, including a decrease in lean body mass.
- Sarcopenia Risk: One study highlights that semaglutide therapy could accelerate sarcopenia, which is muscle loss associated with aging.
It is important for seniors on these medications to be monitored for muscle loss and to discuss any concerns with their healthcare provider.
(References)
- Neeland IJ, Linge J, & Birkenfeld AL. (2024). Changes in lean body mass with glucagon-like peptide-1- .... Diabetes, obesity & metabolism, 38937282.
- Linge J, Birkenfeld AL, & Neeland IJ. (2024). Muscle Mass and Glucagon-Like Peptide-1 Receptor .... Circulation, 39401279.
- Ren Q, Zhi L, & Liu H. (2025). Semaglutide Therapy and Accelerated Sarcopenia in Older .... Drug design, development and therapy, 40631351.
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