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Published on: 8/20/2026

What could cause severe abdominal pain and diarrhea?

Severe abdominal pain and diarrhea are most commonly caused by gut infections such as gastroenteritis (often called stomach flu), but they can also result from other conditions that inflame or irritate the intestines, including food poisoning, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), or certain medications.

Because these symptoms overlap across many conditions—some minor and some serious—identifying the underlying cause quickly matters. Dehydration, high fever, or blood in stool can signal a medical emergency, while milder cases may resolve on their own. Rather than guessing, take a free, instant, online symptom check to better understand possible causes and confidently plan your next steps.

Reviewed for medical accuracy: 07/15/2026

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Explanation

When you get severe stomach pain and diarrhea, it is often because something is upsetting your digestive system. One common reason is gastroenteritis, which is an infection that happens when viruses, bacteria, or sometimes parasites invade your stomach and intestines. This infection makes your tummy hurt and leads to diarrhea as your body tries to flush out the germs. Food poisoning is another possible cause when you eat food that has been contaminated with harmful germs. In some cases, severe symptoms may also be linked to longer-lasting issues, sometimes called chronic diarrhea, where other conditions like inflammatory bowel diseases affect your gut. With these conditions, your body experiences ongoing irritation in the stomach and intestines that causes pain and loose stools. If you have these severe symptoms, especially if you feel very weak or are becoming dehydrated, it is important to identify what's causing your discomfort by taking a free symptom checker test and talking with a doctor. They can help figure out the exact cause and give you the right treatment, so you can start feeling better.

(References)

  • Graves NS. Acute gastroenteritis. Prim Care. 2013 Sep;40(3):727-41. doi: 10.1016/j.pop.2013.05.006. Epub 2013 Jul 19. PMID: 23958366; PMCID: PMC7119329.

  • Descoteaux-Friday GJ, Shrimanker I. Chronic Diarrhea. [Updated 2023 Aug 7]. In: StatPearls [Internet].

  • Updated 2022 Nov 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448082/

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