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Published on: 3/17/2025

What Might Cause Severe Pain in the Lower Middle Abdomen in Females?

Severe pain in the lower middle part of the belly in females can have different causes, such as problems with the gut, issues with the pelvic organs, or other causes.

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Explanation

Severe lower middle abdominal pain in females can stem from several conditions that specifically affect the reproductive system. These include painful menstruation (dysmenorrhea), ovarian cysts, endometriosis (where tissue similar to the uterine lining grows outside the uterus), and uterine fibroids (non-cancerous growths in the uterus). Pelvic inflammatory disease (PID), an infection of the female reproductive organs, can also cause significant pain in this area. Gastrointestinal issues may also cause pain in the lower abdomen. Constipation, Irritable bowel syndrome (IBS), and inflammatory bowel diseases (such as Crohn's disease or ulcerative colitis) can cause pain in the lower middle part of the abdomen. Issues with the urinary system, such as bladder infections or kidney stones, can also manifest as lower abdominal pain. If the pain is severe or does not go away, it’s a good idea to talk with a healthcare provider. They can ask about your symptoms and consider additional tests to find out exactly what is causing the pain.

(References)

  • Cain KC, Headstrom P, Jarrett ME, Motzer SA, Park H, Burr RL, Surawicz CM, Heitkemper MM. Abdominal pain impacts quality of life in women with irritable bowel syndrome. Am J Gastroenterol. 2006 Jan;101(1):124-32. doi: 10.1111/j.1572-0241.2006.00404.x. PMID: 16405544.

  • Reddy J, Barber MD, Walters MD, Paraiso MF, Jelovsek JE. Lower abdominal and pelvic pain with advanced pelvic organ prolapse: a case-control study. Am J Obstet Gynecol. 2011 Jun;204(6):537.e1-5. doi: 10.1016/j.ajog.2011.01.015. Epub 2011 Feb 23. PMID: 21345412.

  • Higaki T, Urushidani S, Kuriyama A, Ikegami T. Mesosalpinx hernia of the sigmoid colon: A cause of lower abdominal pain in women. Clin Case Rep. 2020 Feb 26;8(5):855-857. doi: 10.1002/ccr3.2754. PMID: 32477533; PMCID: PMC7250968.

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