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Published on: 4/7/2025

What Can Cause Sharp Upper Abdominal Pain?

Sharp upper abdominal pain can be caused by problems with organs like your stomach, gallbladder, liver, or pancreas, including inflammation, blockages, or infections.

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Explanation

When you feel a sharp pain in your upper belly, it might be because one of your digestive organs isn’t working as it should. For example, an inflamed stomach lining, called gastritis, or an ulcer can cause pain that comes on quickly and feels sharp. Gallstones in your gallbladder might block the bile flow, causing sudden, intense pain in the upper abdomen. Sometimes, the pancreas can become inflamed in a condition called pancreatitis, which also brings sharp pain along with nausea and vomiting. In people with liver problems, the liver might be swollen or irritated and can cause similar discomfort. The pain often tells us that something inside is not working right, and doctors look at your symptoms closely to decide what tests to run. If you have sharp upper abdominal pain, especially if it comes with other symptoms like fever, vomiting, or it does not get better on its own, it is important to get checked by a healthcare professional for a proper evaluation.

(References)

  • Sherman R. Abdominal Pain. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 86. Available from: https://www.ncbi.nlm.nih.gov/books/NBK412/

  • Riley TR 3rd, Koch K. Characteristics of upper abdominal pain in those with chronic liver disease. Dig Dis Sci. 2003 Oct;48(10):1914-8. doi: 10.1023/a:1026149732756. PMID: 14627332.

  • Grigorian A, Lin MYC, de Virgilio C. Severe Epigastric Pain with Nausea and Vomiting. Surgery. 2019 May 3:227–37. doi: 10.1007/978-3-030-05387-1_20. PMCID: PMC7123429.

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