Sore throat? 5 things people get wrong when selecting OTC medicine

Sore throat? 5 things people get wrong when selecting OTC sore throat medicine

A scratchy, painful throat can ruin your day. With so many over-the-counter (OTC) sore throat medicines on the shelf, it’s easy to grab the first thing you see. But picking the wrong product—or using it the wrong way—can mean wasted money, wasted relief, or even unwanted side effects. Here are five common mistakes people make when choosing a sore throat medicine and how to avoid them.

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1. Treating every sore throat the same way

Not all sore throats are caused by the same thing. Viruses, bacteria, allergies and dry air can all trigger throat pain. Grabbing a medicine designed for one cause may do little for another.

• Viral infections (common cold): Pain relievers like acetaminophen or ibuprofen help ease discomfort, but antibiotics won’t.
• Bacterial infections (strep throat): You’ll need a prescription antibiotic. OTC lozenges or sprays can help with symptoms, but they won’t cure the infection.
• Allergies or post-nasal drip: Antihistamines or nasal rinses may be more effective than lozenges.

Tip: If your sore throat lasts more than a few days, is severe, or comes with high fever, swollen glands or difficulty breathing, speak to a doctor right away—it could be a sign of something more serious.

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2. Ignoring your medical history

Your health background matters when selecting a sore throat medicine. Skipping this step can increase your risks.

• Liver issues and acetaminophen: Acetaminophen is generally safe when used as directed, but exceeding 4,000 mg in 24 hours can cause acute liver failure. People with chronic liver disease or heavy alcohol use should stick to lower limits or choose alternative pain relievers. (Lee WM, 2004)
• Kidney or heart conditions and NSAIDs: Ibuprofen, naproxen and flurbiprofen (found in certain lozenges) can worsen fluid retention, increase blood pressure and strain the kidneys. If you have cirrhosis, kidney disease or heart failure, ask your doctor before using NSAIDs. (Qamar & Grace, 2009)
• Hyponatremia risk: Some multi-symptom cold products contain high-water content syrups or dextrose, which can contribute to low sodium levels in people with cirrhosis. Always read labels and check with your provider if you have liver disease.

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3. Assuming all throat lozenges are identical

Lozenges may look alike, but their active ingredients vary—and so do their effects.

• Menthol lozenges work by providing a cooling sensation and mild numbing.
• Benzocaine or phenol lozenges deliver local anesthesia to temporarily numb throat pain.
• NSAID lozenges (e.g., flurbiprofen) combine pain relief with a targeted anti-inflammatory action right at the sore spot. Studies show flurbiprofen lozenges can reduce throat pain intensity significantly within minutes and maintain relief for hours. (Eccles et al., 2005)

Choosing the right lozenge:

• For quick numbing: benzocaine or phenol.
• For longer-lasting anti-inflammatory relief: flurbiprofen.
• For mild cooling comfort: menthol.

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4. Overlooking hidden ingredients and dosing overlaps

Many OTC cold and flu remedies combine multiple ingredients. You may inadvertently take two products with the same active drug, risking an overdose.

Common overlap concerns:

• Acetaminophen: Often in pain relievers, cold/flu pills, multi-symptom syrups. Taking more than one acetaminophen-containing product can exceed safe limits.
• Decongestants (pseudoephedrine, phenylephrine): Combined in both cold pills and sinus sprays; excess use can raise blood pressure and cause insomnia.
• Cough suppressants and expectorants: Dextromethorphan or guaifenesin may be in several syrups—check to avoid doubling up.

Always:

• Read the active ingredient list on every package.
• Keep a list of what you’re taking and how much.
• Stick to the recommended dose and interval.

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5. Skipping proper dosing instructions and duration limits

More medicine doesn’t always mean more relief—and it can lead to side effects.

• Timing and dosage: Follow label instructions for adult vs. child dosing. Set a timer if needed to avoid taking doses too close together.
• Maximum duration: Many OTC sore throat remedies are meant for short-term use (2–3 days). If pain persists beyond 7 days, see a healthcare professional.
• Lozenges vs. sprays vs. pills: Each form has its own recommended frequency. Lozenges may be every 2–3 hours, sprays up to every 3 hours, pills every 4–6 hours.

Danger of overuse:

• NSAIDs: Exceeding daily limits can cause gastrointestinal bleeding, kidney damage and increased cardiovascular risk.
• Local anesthetics: Overuse of benzocaine can rarely lead to a serious blood disorder called methemoglobinemia.

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When to get extra help

If you’re ever unsure about your symptoms or which OTC sore throat medicine to choose, consider doing a free, online symptom check for to help guide your next steps. And remember—if you experience any of the following, speak to a doctor immediately:

• Severe or worsening throat pain
• Difficulty breathing or swallowing
• High fever (over 101°F/38.3°C)
• Swelling of the neck or face
• Blood in saliva or phlegm

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Selecting the right sore throat medicine doesn’t have to be a guessing game. By understanding your cause, checking your health history, reading labels carefully and following dosing directions, you can find fast, targeted relief and avoid unnecessary risks. And if you ever have doubts or serious symptoms, don’t hesitate to speak to your doctor.