Our Services
Medical Information
Helpful Resources
Published on: 2/28/2026
Lactulose often takes 24 to 72 hours to work because it gently draws water into the colon rather than forcing contractions, so consistent dosing, good hydration, and patience are key.
There are several factors to consider. Medically approved next steps include optimizing fiber and fluids, discussing polyethylene glycol or a short term stimulant with a clinician, and evaluating for underlying causes or prescription options, with urgent care needed for red flag symptoms; see the complete guidance below for details that can change which next step is right for you.
If you're taking lactulose and still feel constipated, you're not alone. Many people expect fast relief—but lactulose doesn't work like a stimulant laxative. It's slower, gentler, and works in a very specific way inside your colon.
Let's break down why lactulose can feel slow, what's normal, and what medically approved next steps you can consider if you're still uncomfortable.
Lactulose is an osmotic laxative. That means it pulls water into your colon to soften stool and make it easier to pass.
Unlike stimulant laxatives (like senna or bisacodyl), lactulose:
After you swallow lactulose, it travels to the large intestine mostly undigested. There, bacteria break it down into acids. These acids:
This process takes time.
For constipation, lactulose usually works within 24 to 48 hours.
For some people, it can take up to 72 hours to see consistent results.
If you were expecting same-day relief, that delay can feel frustrating—but it's normal.
There are several common reasons lactulose may not be working as expected.
Lactulose often works best when taken regularly for several days. A single dose may not be enough.
If you just started, give it:
Lactulose pulls water into the bowel—but your body needs water available to move.
If you're dehydrated, lactulose may:
Most adults should aim for steady fluid intake throughout the day unless a doctor has restricted fluids.
Doctors often start with a moderate dose to reduce side effects like gas or cramping.
If constipation continues:
Never increase lactulose without medical guidance.
Not all constipation is the same.
You may have:
Lactulose works best for typical functional constipation. It may not fully treat other causes.
Common lactulose side effects include:
These symptoms can make you feel worse even if stool is slowly softening.
These effects often improve after several days as your body adjusts.
If you're still constipated after several days on lactulose, here are evidence-based next steps doctors often consider.
Fiber helps stool hold water and move more easily.
Adults typically need:
Good sources:
However, if you suddenly increase fiber without enough water, symptoms may worsen.
Polyethylene glycol (PEG) is often recommended as a first-line treatment in many guidelines. It may:
This should be discussed with a healthcare provider.
If stool is stuck or very hard, a doctor may recommend:
These stimulate bowel contractions. They're generally used short-term, not daily without supervision.
If constipation is ongoing or worsening, your doctor may assess for:
They may recommend:
For chronic constipation not responding to over-the-counter treatments, doctors may prescribe medications that:
These are typically reserved for persistent cases.
Most constipation is not dangerous. But you should speak to a doctor urgently if you experience:
These symptoms can indicate obstruction or another serious condition.
Do not ignore them.
Sometimes what feels like constipation may involve:
If you're struggling to understand what's causing your symptoms, you can use a free AI-powered Constipation symptom checker to help identify potential causes and determine whether your situation requires immediate medical attention.
If you and your doctor decide to continue lactulose, here are practical tips:
Remember: Lactulose works gradually. It is not meant for immediate relief.
For many people, constipation improves with:
Chronic constipation is common and treatable. But it sometimes requires a structured plan—not just a single medication.
If you're still constipated while taking lactulose, it does not automatically mean something is wrong. Lactulose:
If symptoms persist beyond a week despite proper use—or if you develop red-flag symptoms—it's important to speak to a doctor. Constipation is usually manageable, but persistent or severe symptoms deserve medical evaluation to rule out serious conditions.
Relief is possible. It just may require the right combination of treatment, patience, and medical guidance.
(References)
* Ford AC, et al. Pharmacological Management of Chronic Idiopathic Constipation in Adults. Am J Gastroenterol. 2021 Jan 1;116(1):16-29. doi: 10.14309/ajg.0000000000001031. PMID: 33409477.
* Lacy BE, et al. ACG Clinical Guideline: Management of Chronic Constipation. Am J Gastroenterol. 2021 Jul 1;116(7):1321-1341. doi: 10.14309/ajg.0000000000001309. PMID: 34220037.
* Rao SSC. Management of Chronic Constipation in Adults: An Update. Gastroenterol Clin North Am. 2020 Jun;49(2):207-229. doi: 10.1016/j.gtc.2020.02.001. Epub 2020 Apr 17. PMID: 32414571.
* Camilleri M, et al. Pharmacologic Treatment for Chronic Constipation in Adults. Clin Gastroenterol Hepatol. 2023 Feb;21(2):292-302.e1. doi: 10.1016/j.cgh.2022.09.020. Epub 2022 Sep 27. PMID: 36179979.
* Bharucha AE, Lacy BE. Polyethylene Glycol and Other Osmotic Laxatives in Chronic Constipation. Gastroenterol Clin North Am. 2021 Jun;50(2):279-291. doi: 10.1016/j.gtc.2021.02.003. Epub 2021 May 20. PMID: 34024505.
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.