Doctors Note Logo

Published on: 2/25/2026

Still in Pain? Why Diclofenac Sodium Works & Medically Approved Next Steps

Diclofenac sodium reduces inflammatory pain by blocking COX-1 and COX-2 to lower prostaglandins, making it effective for acute low back pain, arthritis, and minor injuries; oral forms often help within 30 to 60 minutes, while topical versions may take several days.

If your pain is not improving after 1 to 2 weeks, medically approved next steps include reassessing the diagnosis, starting physical therapy, considering combination treatments, and making lifestyle changes while watching for red flags and safety issues like ulcers, heart or kidney disease, pregnancy, and blood thinners. There are several factors to consider; see below for dosing, timing, safety risks, who should avoid it, and how to choose the right next step.

answer background

Explanation

Still in Pain? Why Diclofenac Sodium Works & Medically Approved Next Steps

If you're still in pain despite rest, stretching, or over-the-counter remedies, you're not alone. Muscle strains, joint inflammation, arthritis, and acute low back pain are some of the most common reasons people seek medical care. One medication frequently recommended by doctors for short-term pain relief is diclofenac sodium.

But how does diclofenac sodium actually work? When is it appropriate? And what should you do if your pain doesn't improve?

Let's break it down clearly and honestly.


What Is Diclofenac Sodium?

Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAID). It's used to reduce:

  • Pain
  • Inflammation
  • Swelling
  • Stiffness

Doctors commonly prescribe diclofenac sodium for:

  • Acute low back pain
  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Muscle injuries
  • Sprains and strains
  • Post-surgical pain

It's available in multiple forms:

  • Oral tablets (immediate or extended-release)
  • Topical gels
  • Topical patches
  • Injectable forms (in clinical settings)

Each form works slightly differently depending on how it's absorbed.


How Diclofenac Sodium Works

Pain from injuries or arthritis is often driven by inflammation. When tissues are damaged, your body releases chemicals called prostaglandins. These chemicals increase:

  • Swelling
  • Tenderness
  • Sensitivity to pain

Diclofenac sodium blocks enzymes (COX-1 and COX-2) that help produce prostaglandins. With fewer prostaglandins:

  • Inflammation decreases
  • Swelling reduces
  • Pain signals calm down

This is why diclofenac sodium can feel more effective than simple pain relievers like acetaminophen, which do not reduce inflammation.


Why Diclofenac Sodium May Work When Other Pain Relievers Don't

Not all pain is the same.

If your pain is mainly inflammatory—such as from arthritis or a muscle strain—an NSAID like diclofenac sodium can be more effective than medications that only block pain signals.

Diclofenac sodium is often considered:

  • Stronger than over-the-counter ibuprofen (depending on dose)
  • Effective for short-term flare-ups
  • Useful for targeted joint or back pain

Topical diclofenac sodium can be especially helpful if you want relief directly at the site of pain with less overall body exposure.


When Diclofenac Sodium Is Most Appropriate

Doctors often recommend diclofenac sodium for:

✅ Acute Low Back Pain

  • Sudden pain after lifting or twisting
  • Muscle strain
  • Inflammatory flare-ups

If you're experiencing sudden back pain and want to understand whether your symptoms require immediate medical attention, you can use a free Acute Low Back Pain symptom checker to help determine your next steps.

✅ Arthritis Pain

  • Joint stiffness in the morning
  • Swollen joints
  • Pain that worsens with movement

✅ Short-Term Injury Relief

  • Sports injuries
  • Minor sprains
  • Tendon inflammation

It is generally not meant as a long-term daily solution unless closely monitored by a healthcare provider.


How Long Does Diclofenac Sodium Take to Work?

  • Oral tablets: Often begin working within 30–60 minutes
  • Topical gel: May take several days of consistent use
  • Extended-release versions: Provide longer-lasting control

For acute pain, many people notice meaningful improvement within a few days.

If pain persists beyond 1–2 weeks despite treatment, it's time to reassess with a healthcare professional.


Important Safety Information (Without the Panic)

Like all NSAIDs, diclofenac sodium has risks. Most people tolerate it well when used correctly and for short periods. However, it is important to understand potential concerns.

Common Side Effects

  • Stomach upset
  • Heartburn
  • Nausea
  • Mild dizziness

More Serious Risks (Especially With Long-Term Use)

  • Stomach ulcers or bleeding
  • Increased blood pressure
  • Kidney strain
  • Increased cardiovascular risk in certain individuals

These risks are more likely if you:

  • Use high doses
  • Take it long-term
  • Have heart disease
  • Have kidney problems
  • Are over 65
  • Take blood thinners

This doesn't mean you should avoid diclofenac sodium—but it does mean you should use it responsibly and under medical guidance if you have underlying conditions.


Who Should Not Use Diclofenac Sodium Without Medical Advice?

Speak to a doctor first if you:

  • Have heart disease
  • Have a history of stroke
  • Have stomach ulcers
  • Have kidney disease
  • Are pregnant (especially in the third trimester)
  • Take blood thinners
  • Take other NSAIDs

If you experience:

  • Chest pain
  • Shortness of breath
  • Black or bloody stools
  • Severe stomach pain
  • Sudden weakness or numbness

Seek medical care immediately. These symptoms can signal serious complications.


What If Diclofenac Sodium Isn't Enough?

If your pain continues despite diclofenac sodium, the next step depends on the cause.

Medically Approved Next Steps May Include:

1. Re-Evaluation of Diagnosis

Sometimes persistent pain means:

  • The injury is more severe than expected
  • There is nerve involvement
  • There is disc-related back pain
  • Arthritis has progressed

Imaging or a physical exam may be necessary.

2. Physical Therapy

Especially for back pain and joint pain, physical therapy can:

  • Improve mobility
  • Strengthen support muscles
  • Prevent recurring flare-ups

Medication alone rarely solves mechanical pain long-term.

3. Combination Therapy

Doctors may combine:

  • NSAIDs like diclofenac sodium
  • Muscle relaxants (short-term)
  • Topical treatments
  • Heat or cold therapy

4. Lifestyle Adjustments

Evidence shows that small changes can significantly reduce inflammation:

  • Regular low-impact exercise
  • Weight management
  • Core strengthening
  • Posture correction

These steps reduce dependency on medications over time.


How Long Should You Take Diclofenac Sodium?

For acute injuries, most doctors recommend:

  • The lowest effective dose
  • For the shortest duration possible

Often 5–14 days is sufficient for acute pain.

Chronic conditions like arthritis may require longer treatment—but under supervision with regular monitoring.


Practical Tips for Using Diclofenac Sodium Safely

  • Take oral forms with food to reduce stomach irritation
  • Do not combine with other NSAIDs unless directed
  • Avoid excessive alcohol
  • Follow prescribed dosing exactly
  • Do not double up if you miss a dose

If using topical diclofenac sodium:

  • Apply only to intact skin
  • Wash hands after use
  • Avoid covering with tight bandages unless instructed

When Pain Is a Warning Sign

Most back and joint pain improves within weeks. However, you should speak to a doctor promptly if pain is accompanied by:

  • Fever
  • Unexplained weight loss
  • Loss of bowel or bladder control
  • Progressive weakness
  • Pain after a major fall or accident

These could signal more serious conditions that require immediate evaluation.


The Bottom Line

Diclofenac sodium works because it directly targets inflammation, which is often the root cause of pain in joints, muscles, and the lower back. For short-term relief, it can be highly effective and medically appropriate when used correctly.

However:

  • It is not a cure
  • It is not risk-free
  • It should not replace proper diagnosis

If your pain is lingering, worsening, or affecting your daily life, it's worth investigating further. Consider starting with a free online Acute Low Back Pain symptom checker and then follow up with a healthcare professional.

Most importantly, if your symptoms feel severe, unusual, or potentially life-threatening, speak to a doctor immediately. Prompt medical care can prevent complications and ensure you get the right treatment—not just temporary relief.

Pain is common. Ongoing, unexplained, or worsening pain deserves attention.

Used wisely, diclofenac sodium can be part of an effective plan—but it works best when combined with proper diagnosis, safe use, and medical guidance.

(References)

  • * Rainsford, K. D. (2012). Diclofenac: an update on its mechanism of action and safety profile. *Current Medical Research and Opinion*, *28*(8), 1335–1355. PMID: 22692067.

  • * Reay, G. E. L., Lamy, A., & Moore, R. A. (2020). Diclofenac for the treatment of pain in adults. *Cochrane Database of Systematic Reviews*, *(11)*, CD013689. PMID: 33170757.

  • * Bhavsar, S. B., Amin, S. B., & Pithadia, A. B. (2014). Nonsteroidal anti-inflammatory drugs in the management of acute and chronic pain. *Journal of Clinical and Diagnostic Research: JCDR*, *8*(7), LE01-LE04. PMID: 25068997.

  • * Laine, D. M., & Laine, L. (2014). Risk of serious gastrointestinal events with the use of diclofenac: a systematic review and meta-analysis. *Gastroenterology and Hepatology*, *36*(7), 532–540. PMID: 24034630.

  • * Macfarlane, G. J., & Kronisch, C. (2017). Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic musculoskeletal pain: systematic review and meta-analysis. *Pain*, *158*(12), 2320–2332. PMID: 29095655.

Thinking about asking ChatGPT?Ask me instead

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Learn more about diseases

Acute Low Back Pain

Was this page helpful?

Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.