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Published on: 1/20/2026
Yes, stress can cause diarrhea by activating the gut-brain axis; hormones like cortisol and CRF can speed intestinal transit, heighten gut sensitivity, and shift microbiota, leading to loose, urgent stools. There are several factors and red flags to consider; see the complete details below for who is more at risk, practical relief steps like stress reduction and diet changes, and when to seek medical care to guide your next steps.
Diarrhea—loose, frequent stools—is often blamed on infections or food triggers. Yet stress can also play a significant role. Research shows that emotional and psychological stress can disrupt normal gut function, leading to diarrhea in many individuals. Below, we explore how stress affects the digestive system, the evidence behind stress-related diarrhea, practical tips for relief, and when to seek medical help.
The brain and gut communicate constantly via the gut-brain axis. When you’re stressed, this communication is altered in several ways:
Activation of the HPA Axis
Stress triggers the hypothalamic-pituitary-adrenal (HPA) axis, increasing cortisol and adrenaline levels. These hormones can speed up intestinal transit, reducing water absorption and causing loose stools.
Release of Corticotropin-Releasing Factor (CRF)
CRF, a stress hormone, directly influences gut motility and permeability. Animal and human studies (Barbara & De Giorgio, 2002) show CRF can induce diarrhea by overstimulating colon contractions.
Altered Enteric Nervous System Function
Psychological stress can heighten sensitivity of the enteric nervous system (“the gut’s own brain”), making normal movements feel uncomfortable and more urgent.
Changes in Gut Microbiota
Chronic stress may shift the balance of gut bacteria. Disruptions in microbiota can impair digestion and absorption, increasing the risk of diarrhea.
Increased Intestinal Permeability
Known as “leaky gut,” stress-induced permeability allows water and inflammatory molecules into the gut lumen, triggering rapid stool passage (Barbara & Cremon, 2002).
Several key studies illuminate the connection between stress and diarrhea:
Additional research supports these findings:
Not everyone under stress develops diarrhea, but certain factors raise the likelihood:
When stress triggers diarrhea, you may notice:
Unlike infectious diarrhea, stress-related episodes usually lack fever or blood in the stool.
Although stress can’t always be eliminated, you can adopt tactics to minimize its impact on your gut:
Persistent or severe diarrhea can lead to dehydration, weight loss, and nutrient deficiencies. Consider professional evaluation if you experience:
For an initial assessment, you might try a free, online symptom check to help clarify your symptoms and decide on next steps.
Always share new or worsening symptoms with a healthcare professional. Be ready to discuss:
Your doctor may recommend blood tests, stool studies, or imaging to rule out infections, inflammatory conditions, or structural issues.
Stress-related diarrhea can often be managed with lifestyle changes and stress-relief techniques. Yet, it’s important to remain vigilant: any sign of dehydration, bleeding, or systemic illness warrants prompt medical attention. If you’re unsure what’s causing your symptoms, try a free, online symptom check and follow up with your healthcare provider for personalized care.
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