Can sunscreen interact with medications?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Sunscreen itself does not interact with medications. However, certain medications—such as antibiotics, diuretics, retinoids, and some antidepressants—can cause photosensitivity, making your skin more prone to sunburn or rashes even when sunscreen is applied. If you're taking these drugs, you may need stronger sun protection, reapplication more often, or additional measures like protective clothing and shade.

If you've noticed unusual skin reactions, burns, or rashes after sun exposure while on medication, it's important to identify the cause quickly. Take a free, instant, online symptom check to better understand your symptoms, uncover possible causes, and get clear guidance on your next steps—all in just a few minutes, from the comfort of home.

Reviewed for medical accuracy: 07/20/2026

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Explanation

Sunscreens are designed to protect your skin from the harmful effects of the sun. However, certain medications can make your skin more sensitive to sunlight, a condition known as photosensitivity.

Photosensitivity and Medications

Photosensitivity: This is when your skin reacts more to sunlight than usual. It can cause sunburns or rashes. Some medicines can cause this reaction.
Medicines that cause photosensitivity: According to the references, drugs like amiodarone can make your skin more sensitive to sunlight. This means you might get a sunburn or rash even if you use sunscreen.

What You Can Do

Use Sunscreen: Continue using sunscreen to protect your skin, but be aware that it might not fully prevent reactions if you are taking certain medications.
Seek Shade: Stay out of direct sunlight, especially during peak hours.
Wear Protective Clothing: Hats and long sleeves can provide extra protection.

If you notice your skin reacting to the sun more than usual or experiencing unexpected symptoms, you can check your symptoms to better understand what might be happening. It's also a good idea to talk to your doctor, as they can help you determine if your medication might be causing photosensitivity.

(References)

Moore DE. (2002). Drug-induced cutaneous photosensitivity: incidence, .... Drug safety, 12020173.
Gu X, Dannefaer JL, & Collins BR. (2008). In vitro permeation characterization of the analgesic .... Drug development and industrial pharmacy, 18618308.
Walter JF, Bradner H, & Curtis GP. (1984). Amiodarone photosensitivity. Archives of dermatology, 6508331.

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