At What Age Might Testicles Start Shrinking Due to Hormonal Changes or Treatments Like TRT?

Our bodies slowly change as we get older. In men, natural testosterone levels tend to fall over time, and some studies note that testicles may start to shrink during middle age—often noticeable around the 40s or 50s. This process happens because of age-related changes in hormones and the normal aging of the testicular tissue. When a man uses testosterone replacement therapy (TRT) to boost his testosterone levels, the body can reduce its own production of this hormone. This reduction can cause the testicles to become smaller because they no longer need to work as hard to produce testosterone. It is important to note that everyone is different, and the timing of these changes can vary based on individual health and genetics. Also, while some decrease in size might occur with testosterone treatment, many factors, such as overall health and other therapies, can influence this process. If there are concerns about changes in testicular size or hormone levels, it is best to talk with a healthcare provider to understand what is happening for that individual.